Evidence map›Paper›PMID 41884324›Full record

ArticleFrontiers in toxicology2026

Deciphering the toxicological mechanism of airway allergic diseases caused by dioctyl terephthalate: a composite study.

Zhi-Qiang Zhang, You-Wei Bao, Hongyou Wang, Jing-Yang Li, Heng Wang, Xinyue Yang, Qi Chen, Jun Wu, Xin-Hua Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhi-Qiang Zhang *Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
You-Wei Bao *Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Hongyou WangDepartment of Anesthesiology, The First Hospital of Jinlin University, Changchun, China.
Jing-Yang LiDepartment of Clinical Medicine, The First Clinical Medical College, Nanchang University, Nanchang, China.
Heng WangChina-Japan Union Hospital of Jilin University, Changchun, China.
Xinyue YangDepartment of Clinical Medicine, The First Clinical Medical College, Nanchang University, Nanchang, China.
Qi ChenDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Jun WuDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Xin-Hua ZhuDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Dioctyl terephthalate (DOTP), a common plasticizer alternative, has unclear immunotoxic effects on respiratory allergic diseases such as allergic rhinitis (AR), asthma (AS), chronic rhinosinusitis (CRS), and allergic bronchopulmonary aspergillosis (ABPA). Methods: We integrated network toxicology, target mining, bioinformatics, and machine learning to explore DOTP's potential role in allergic airway diseases. Shared targets were analyzed via PPI networks, enrichment analyses, immune profiling, single-cell data, and molecular docking. Key genes were validated Results: DOTP showed potential toxicity including carcinogenicity and nephrotoxicity. It shared 136 targets with allergic diseases, mainly involved in immune and apoptotic pathways. EGFR, BCL2, CFTR, SYK, and C3AR1 were identified as core genes. DOTP showed strong binding to these targets and induced cytotoxicity and gene expression changes in epithelial cells. Conclusion: DOTP may promote allergic airway diseases via immune-related and multi-target mechanisms. These findings highlight potential health risks of DOTP exposure and warrant further investigation.

Indexed as

airway allergic diseasesallergic rhinitiscomposite studydioctyl terephthalatetoxicological mechanism

Identifiers

PMID41884324
PMCPMC13012849

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.