ArticleInternational journal of nanomedicine2026
High Dihydromyricetin Loaded Biomimetic Nanoemulsion Ameliorated Early Nonalcoholic Fatty Liver Disease by Hepatic Ferroptosis Inhibition.
Article in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Flavonoids in MASLD: preclinical mechanisms, pharmacological targets, and translational challenges.Frontiers in pharmacology · 2026Review
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Authors and funding
6 authors.
Funding
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Abstract
Introduction: Nonalcoholic fatty liver disease (NAFLD) is a metabolic disorder characterized by lipid accumulation in the liver, and is often linked to ferroptosis, an iron-dependent programmed cell death driven by lipid peroxidation. Dihydromyricetin (DMY), a flavonoid from Ampelopsis grossedentata, exhibits anti-NAFLD efficiency but has low bioavailability. In this study, a high DMY-loaded biomimetic nanoemulsion (DMY-bNE) was developed using a double emulsification method with glyceryl monooleate. Methods: DMY-bNE was characterized in vitro and in vivo including encapsulation efficiency (EE), drug-loading capacity (DLE), gastrointestinal (GI) absorption, biodistribution, pharmacokinetics, safety. High fat diet induced NAFLD mouse model was used to investigate the therapeutic effect and mechanism. Results: DMY-bNE showed high EE (99.5%) and DLE (24.9%), promoted GI absorption, enhanced liver accumulation, improved pharmacokinetic properties and good in vivo safety. In NAFLD mice, DMY-bNE significantly ameliorated the disease progression by inhibiting hepatic ferroptosis. Conclusion: These findings demonstrated that DMY-bNE combines enhanced drug delivery with ferroptosis inhibition, thereby offering a promising strategy for NAFLD therapy.
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