Evidence map›Paper›PMID 41884261›Full record

ArticleFrontiers in physiology2026

Adipocyte fatty acid-binding protein 4 suppresses contraction of mouse ventricular myocytes via a calcium-independent pathway.

Cuihua Wang, Daofeng You, Xuan Jiang, Shanshan Han, Fenghong Liu, Wei Wang, Mingqi Zheng

Abstract read
In one paragraph

Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cuihua Wang *Department of Cardiac Rehabilitation, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Daofeng You *Emergency Department, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Xuan JiangArrhythmia Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Shanshan HanDepartment of Cardiac Rehabilitation, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Fenghong LiuDepartment of Cardiac Rehabilitation, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Wei Wang *Cardiovascular Disease Research Institute, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, China.
Mingqi Zheng *Arrhythmia Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Adipocyte Fatty Acid-Binding Protein 4 (FABP4) exerts a direct negative inotropic effect on cardiac muscle, but the underlying cellular mechanisms remain elusive. This study aimed to dissect the specific effects of FABP4 on the contractility and calcium (Ca Methods: Contractility and intracellular Ca Results: FABP4 inhibited myocyte contraction in a biphasic, dose-dependent manner, with a high-affinity (EC Conclusion: Full-length FABP4 suppresses cardiomyocyte contractility primarily through a Ca

Indexed as

calcium transientscontractilityFABP4myofilament sensitivityventricular myocytes

Identifiers

PMID41884261
PMCPMC13008700

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.