ArticleWorld journal of nephrology2026
Renal elasticity assessment in patients of glomerulonephritis by shear-wave elastography and its correlation with histopathology and renal biomarkers.
Article in World journal of nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Renal elastography in kidney disease: Current evidence, limitations, and future directions.World journal of nephrology · 2026Review
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10 authors.
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Abstract
backgroundGlomerulonephritis (GN) is a major cause of chronic kidney disease and end-stage renal disease. Renal biopsy remains the gold standard for assessing interstitial fibrosis and tubular atrophy (IF/TA), but it is invasive and unsuitable for repeated assessments. Shear-wave elastography (SWE) is a promising non-invasive technique for quantifying renal cortical stiffness.
aimTo evaluate renal elasticity using SWE in patients with GN and correlate SWE values with histopathology and serum transforming growth factor-β1 (TGF-β1) levels.
methodsThis prospective study included 201 consecutive adults with suspected GN undergoing renal biopsy. SWE was performed using a standardized protocol (6 cortical measurements per kidney). Histopathological IF/TA grade served as the reference standard. Serum TGF-β1 was measured using ELISA. Receiver operating characteristic analysis, analysis of variance, and Pearson correlation were applied. Additionally, 53 patients underwent follow-up SWE after 3-6 months.
resultsPatients were classified as: No fibrosis (
conclusionSWE correlates strongly with histological fibrosis in GN, outperforming conventional ultrasound and serum TGF-β1. It may serve as a non-invasive surrogate marker for moderate-to-marked fibrosis and assist in minimizing unnecessary biopsies. SWE also demonstrates potential for monitoring disease progression.
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