ArticleJournal of inflammation research2026
Two-Dimensional PCR for Simultaneous Detection of Fecal Bacterial Markers in the Diagnosis and Management of Inflammatory Bowel Disease.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Inflammatory bowel disease (IBD) is showing an increasing incidence in China, posing a significant threat to public health. IBD patients exhibit gut microbiota dysbiosis, and detection of IBD-associated gut microbes can aid in diagnosis and management. Methods: We developed a 2D-PCR method based on base-quenching probe technology, which allowed closed-tube, single-tube simultaneous detection of four IBD-associated microbes: Results: The 2D-PCR method was demonstrated a detection limit of 10 copies/μL and no cross-reactivity between primers. The combination of Conclusion: The 2D-PCR method is cost-effective and suitable for widespread clinical application with low technical and instrumental requirements. These detected microbial markers could aid in IBD diagnosis, differential diagnosis, and treatment guidance, serving as noninvasive biomarkers and expanding the clinical utility of gut microbiota in IBD management.
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