ReviewJournal of inflammation research2026
Optimal Antibiotic Selection for the Treatment of Pouchitis After Ileal Pouch-Anal Anastomosis.
Review in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pouchitis is the most common complication following ileal pouch-anal anastomosis for ulcerative colitis. Antibiotics remain the cornerstone of therapy for acute and chronic antibiotic dependent pouchitis, though evidence guiding their optimal use is limited. Material and Methods: A comprehensive literature search of PubMed, MEDLINE, Embase, and Google Scholar was conducted from database inception through October 2025 to identify studies evaluating antibiotic therapy for acute pouchitis. Eligible studies included randomized controlled trials, cohort studies, and observational series reporting clinical, endoscopic, or histologic outcomes. Data were extracted from 10 studies on study design, antibiotic regimen, efficacy, safety, and recurrence. Results: Data on the optimal selection of antibiotics for pouchitis is limited. Ciprofloxacin and metronidazole are the most extensively studied and commonly prescribed antibiotics. In a randomized clinical trial, ciprofloxacin demonstrated superior efficacy and tolerability compared with metronidazole. Rifaximin and vancomycin show potential benefit in selected cases. Conclusion: Antibiotic therapy provides rapid and effective symptom control in most patients with acute pouchitis. Ciprofloxacin should be considered first-line, with metronidazole or combination therapy reserved for non-responders.
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