ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2026
Association Between Subclinical Albuminuria and Early Arterial Stiffness in Chinese Adults with Type 2 Diabetes.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Sex Differences in the Cardiovascular Significance of Albuminuria in Type 2 Diabetes: A Narrative Review.Journal of clinical medicine · 2026Review
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: While elevated microalbuminuria is closely associated with arterial stiffness, the relationship between high-normal albuminuria and arterial stiffness remains unclear among Chinese adults with type 2 diabetes. Objective: This study aimed to investigate the association between subclinical albuminuria and early arterial stiffness in a cohort of Chinese adults with T2DM, focusing on sex-specific differences and threshold effects. Methods: In this cross-sectional study, 1119 Chinese adults with type 2 diabetes and without overt kidney or cardiovascular disease were enrolled. Arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV). Participants were stratified by tertiles of the logarithmically transformed urinary albumin-to-creatinine ratio (lg-UACR). We employed correlation analysis to examine continuous relationships and multivariable logistic regression to assess the odds of high baPWV across lg-UACR tertiles. Sex-stratified and restricted cubic spline analyses were conducted to explore effect modification and nonlinearity. Results: Higher lg-UACR tertiles demonstrated a dose-dependent association with arterial stiffness risk in the overall cohort. Sex-stratified analysis revealed this association was statistically significant only in women. Among postmenopausal women, a threshold effect was observed at lg-UACR =1.1 (UACR =12.6 mg/g), beyond which the significant correlation between microalbuminuria and arterial stiffness was attenuated. Conclusion: Elevated UACR in normal range is associated with arterial stiffness risk in Chinese women with type 2 diabetes, but not in men. Among postmenopausal women, this link is significant only below a lg-UACR threshold of 1.1 and is abolished at or above this level. This critical threshold effect, modulated by menopause, suggests sex-specific UACR criteria for vascular risk assessment.
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