Evidence map›Paper›PMID 41884045›Full record

ArticleWorld journal of clinical pediatrics2026

Effects of omega-3 fatty acid supplementation on heart rate variability.

Hoda Atef Abdelsattar Ibrahim, Kamal Gouda Kamal, Mohamed Khaled Ali Mohamed Ali Zid, Albraa Ashraf Hamad, Ayesha Kuraishi, Marwa Taha

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In one paragraph

Article in World journal of clinical pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Hoda Atef Abdelsattar IbrahimDivision of Pediatric Clinical Nutrition, Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo 12613, Egypt. hodaibrahim424@gmail.com.
Kamal Gouda KamalUndergraduate students, Dr. Hoda Atef Abdelsattar Ibrahim's Research Group, Faculty of Medicine, Cairo University, Cairo 12613, Egypt.
Mohamed Khaled Ali Mohamed Ali ZidUndergraduate students, Dr. Hoda Atef Abdelsattar Ibrahim's Research Group, Faculty of Medicine, Cairo University, Cairo 12613, Egypt.
Albraa Ashraf HamadUndergraduate students, Dr. Hoda Atef Abdelsattar Ibrahim's Research Group, Faculty of Medicine, Cairo University, Cairo 12613, Egypt.
Ayesha KuraishiUndergraduate students, Dr. Hoda Atef Abdelsattar Ibrahim's Research Group, Faculty of Medicine, Cairo University, Cairo 12613, Egypt.
Marwa TahaDepartment of Pediatrics, Mataria Teaching Hospital, General Organization for Teaching Hospitals and Institutes, Cairo 11756, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity and overweight are major public health challenges and are associated with autonomic imbalance and decreased heart rate variability (HRV), a non-invasive indicator of cardiovascular risk. Omega-3 polyunsaturated fatty acids have shown cardioprotective effects and may modulate autonomic function. Nevertheless, the effect of omega-3 supplementation on HRV in individuals who are overweight or obese remains unclear.

aimTo study the effect of omega-3 supplementation on HRV in overweight and obese individuals and to explore the heterogeneity across different study designs.

methodsIn accordance with PRISMA guidelines, a systematic review and meta-analysis were conducted. PubMed, Science Citation Index, and Scopus were searched for randomized controlled trials (RCTs) assessing the impact of oral omega-3 supplementation on HRV in overweight or obese participants. Primary outcomes were the impacts of omega-3 supplementation on time-domain HRV indices [root mean square of successive differences (RMSSD), standard deviation of normal-to-normal intervals (SDNN), and percentage of successive normal-to-normal intervals differing by more than 50 milliseconds (pNN50%)], and frequency-domain indices [high-frequency (HF) power, low-frequency (LF) power, and LF/HF ratio].

resultsFour RCTs (

conclusionOmega-3 supplementation represents a promising and low-cost strategy for enhancing autonomic balance and potentially reducing cardiovascular risk in overweight and obese populations, as it improves time-domain HRV measures.

Indexed as

Autonomic nervous systemHeart rate variabilityMeta-analysisObesityOmega-3 polyunsaturated fatty acidsRandomized controlled trials

Identifiers

PMID41884045
PMCPMC13010831

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