ArticleJournal of biomedical optics2026
Repeatability and reliability of retinal arterial hemodynamics measurement using Doppler holography.
Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Significance: Reliable quantification of retinal arterial blood flow is important for diagnosing and monitoring ocular and systemic diseases. Existing techniques are limited by invasiveness, motion artifacts, or a lack of quantitative flow estimation. Aim: The aim is to assess the repeatability, reproducibility, and robustness of laser Doppler holography (LDH) for measuring retinal arterial hemodynamics. Approach: We acquired LDH data at 67 kHz in healthy volunteers (14 eyes intra-day and 4 eyes inter-day) and quantified blood volume rate, resistivity index (RI), and vessel diameter. Additional measurements evaluated sensitivity to axial displacement and gaze lateral positioning. Results: LDH successfully measured retinal arterial blood volume rate in all eyes, with a coefficient of variation (CoV) of 18.5% for the mean arterial blood volume rate and a CoV of 11% for RI. Inter-day reproducibility remained acceptable ( Conclusions: LDH provides reliable and robust measurements of retinal arterial hemodynamics and maintains performance under typical imaging variations (axial or gaze position). These findings support its potential for longitudinal studies and future clinical translation.
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