Transcriptional and cellular maturation of the chick spinal cord in the context of distinct neuromuscular circuits.

Fabio Sacher, Bianka Berki, Antoine Fages, Libby Gavrilov, Avihu Klar, Maëva Luxey, Patrick Tschopp

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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Fabio SacherDUW Zoology, University of Basel, Vesalgasse 1, 4051 Basel, Switzerland.

Bianka BerkiDUW Zoology, University of Basel, Vesalgasse 1, 4051 Basel, Switzerland.

Antoine FagesDUW Zoology, University of Basel, Vesalgasse 1, 4051 Basel, Switzerland.

Libby GavrilovDepartment of Medical Neurobiology, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

Avihu KlarDepartment of Medical Neurobiology, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

Maëva LuxeyDUW Zoology, University of Basel, Vesalgasse 1, 4051 Basel, Switzerland.

Patrick TschoppDUW Zoology, University of Basel, Vesalgasse 1, 4051 Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The chicken spinal cord is a classic model system to study the early specification of neuronal cell types along its anterior-posterior axis. Here, we follow the ensuing maturation dynamics at limb levels with single-cell resolution and contrast neuronal populations innervating appendages of distinct form and function. We use gene co-expression modules to identify rare cell populations with specific biological functions, and show that appendages with different motor outputs - wings and legs - rely on largely similar spinal cord cell type repertoires. Challenging the system with experimental alterations to the peripheral limb musculature reveals limited transcriptional changes, but spatially restricted plasticity in spinal cord motor neuron numbers. Collectively, our results provide a resource to investigate the molecular and cellular basis of neuronal maturation in the avian spinal cord and highlight the plastic nature of embryonic cells to adapt to changes in the limb periphery at both developmental and evolutionary timescales.

Indexed as

Developmental biologyMolecular biologyNeuroscienceOmics

Identifiers

PMID41884005

DOI10.1016/j.isci.2026.115196

PMCPMC13010115

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