SynthesisFrontiers in oncology2026
Prognostic and clinicopathological value of the prognostic nutritional index in prostate cancer treated with androgen deprivation therapy: a systematic review and meta-analysis.
Synthesis in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
5 authors.
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Abstract
Background: The prognostic nutritional index (PNI) has been associated with survival outcomes in multiple solid tumors, yet its prognostic relevance in prostate cancer patients undergoing androgen deprivation therapy (ADT)-based systemic treatment remains insufficiently characterized. Methods: We systematically searched PubMed, Embase, Cochrane Library, Web of Science, and China National Knowledge Infrastructure (CNKI) from database inception to September 11, 2025. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were used to assess the association between PNI and survival outcomes; pooled odds ratios (ORs) with 95% CIs evaluated links with clinicopathological features. Subgroup analyses explored heterogeneity sources. Results: Ten retrospective studies involving 1, 847 patients were included. Low PNI was significantly associated with worse overall survival (HR = 2.082, 95% CI: 1.756-2.469, Conclusions: In the context of ADT-based systemic therapy, low PNI is a significant predictor of poor survival and aggressive disease features, supporting its potential as a readily available biomarker for risk stratification and prognostic assessment in prostate cancer patients. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD420251145397.
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