Multi-omics analysis reveals maternal gut microbiota-derived short-chain fatty acids and progesterone are associated with offspring birth weight in sows.

Xiaojian Xu, Yuwen Chen, Qianhong Ye, Baoyang Xu, Xianghua Yan

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Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Xiaojian XuNational Key Laboratory of Agricultural Microbiology, Frontiers Science Center for Animal Breeding and Sustainable Production, Hubei Hongshan Laboratory, College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.

Yuwen ChenNational Key Laboratory of Agricultural Microbiology, Frontiers Science Center for Animal Breeding and Sustainable Production, Hubei Hongshan Laboratory, College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.

Qianhong YeNational Key Laboratory of Agricultural Microbiology, Frontiers Science Center for Animal Breeding and Sustainable Production, Hubei Hongshan Laboratory, College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.

Baoyang XuCollege of Animal Science and Technology, College of Veterinary Medicine, Zhejiang A&F University, Hangzhou, Zhejiang, China.

Xianghua YanNational Key Laboratory of Agricultural Microbiology, Frontiers Science Center for Animal Breeding and Sustainable Production, Hubei Hongshan Laboratory, College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.

Funding

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6 · The paper itself

Abstract

Introduction: Piglet birth weight is a key determinant of preweaning survival and subsequent growth performance, yet the role of maternal gut microbiota in relation to offspring birth weight in sows remains incompletely characterized. This study aimed to investigate the association between maternal gut microbiota in late gestation and offspring birth weight in sows. Methods: Fecal samples were collected from 260 Landrace × Yorkshire (LY) sows at gestation day 100, and sows were categorized into high birth weight (HBW; 1.41 ± 0.02 kg, 16.25 ± 0.25 piglets/litter, Results: Compared with LBW sows, HBW sows showed distinct bacterial community profiles with higher relative abundances of multiple taxa linked to SCFAs production, including Discussion: In conclusion, these multi-omics data indicate that higher piglet birth weight is associated with an SCFAs-enriched gut microbial ecosystem accompanied by enhanced bile acid and steroid hormone-related fecal metabolic profiles during late gestation.

Indexed as

fecal metabolomicsgut microbiomepiglet birth weightshort-chain fatty acidssowsteroid hormone metabolism

Identifiers

PMID41883788

DOI10.3389/fmicb.2026.1781673

PMCPMC13008854

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