ArticleWorld journal of critical care medicine2026
Determinants of fatal outcome in septic shock patients with euthyroid sick syndrome.
Article in World journal of critical care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSeptic shock is a leading cause of mortality in intensive care, and euthyroid sick syndrome (ESS) may influence outcomes. Identifying predictors of fatal outcome in this population is crucial for guiding management.
aimTo identify clinical and laboratory predictors of 28-day mortality in patients with septic shock and ESS, and to evaluate the prognostic value of markers such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), prognostic index (PI), and modified Glasgow prognostic score (mGPS), the vasoactive drug-dependent index (VDI), and shock index (SI).
methodsIn this prospective observational study, 95 patients with septic shock and ESS admitted between May 2024 and August 2025 were analyzed. Demographic, clinical, and laboratory data were collected at admission and on days 1, 3, and 7. Prognostic markers - NLR, PLR, PI, and mGPS, VDI, and SI were analyzed. Associations with 28-day mortality were evaluated using standard statistical tests.
resultsOf the 95 patients (mean age 61 ± 14.6 years; female/male ratio 52/43), 53 (52%) died. Duration of mechanical ventilation (
conclusionThe 28-day mortality among patients with septic shock and ESS was 52%. Duration of mechanical ventilation, ICU stay, severity scores, laboratory parameters, and indices such as SI and mGPS were significantly associated with outcome. The presence of ESS may contribute to adverse prognosis, and combined evaluation of clinical and laboratory factors can improve risk stratification in this high-risk population.
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