ArticleWorld journal of critical care medicine2026
Burden and impact of acute kidney injury in acute liver failure: A systematic review.
Article in World journal of critical care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute kidney injury (AKI) affects 40%-80% of patients with acute liver failure (ALF) and arises from complex mechanisms, including hemodynamic instability, drug toxicity, and direct renal insults. Unlike chronic liver disease, AKI in ALF is poorly studied.
aimTo consolidate current evidence and guide future research and interventions to improve outcomes in ALF patients with AKI.
methodsThis systematic review followed PRISMA guidelines, searching databases from 2000 to 2024 for studies on AKI in ALF. We included studies focused on adult, English-language, full-length epidemiological studies. Data were extracted on study design, patient demographics, risk factors, and outcomes. Methodological quality was assessed using a tailored 5-point tool. Data were summarized using descriptive statistics and analyzed with GraphPad Prism and MedCalc software.
resultsThis systematic review analyzed nine studies published between 2009 and 2024, encompassing 6031 patients with ALF, of whom 62.9% developed AKI. Most studies were retrospective and varied in methodology, setting, and population. Only three studies reported independent risk factors for the development of AKI among ALF patients, with significant variation in the risk factors studied. AKI in ALF patients significantly increased mortality, with hazard ratios ranging from 2.77 to 11.61. The review highlights the need for standardized diagnostic criteria and risk stratification to guide prevention and improve clinical outcomes in ALF.
conclusionAKI is common in ALF, increasing morbidity and mortality; standardised diagnosis and targeted management strategies are urgently needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.