Evidence map›Paper›PMID 41883703›Full record

ArticleNeurology. Genetics2026

The Genetics of TDP-43 Type C Neurodegeneration: A Whole-Genome Sequencing Study and Literature Review.

Malik Nassan, Ivan Ayala, Jennifer Sloan, Anna Bonfitto, Bobbi Stark, Serena Song, Marcus Naymik, Changiz Geula, Tamar Gefen, Elena Barbieri and 3 more

Abstract read
In one paragraph

Article in Neurology. Genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Malik NassanMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, IL; and.ORCID https://orcid.org/0000-0002-6182-4340
Ivan AyalaMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, IL; and.ORCID https://orcid.org/0009-0005-8133-5914
Jennifer SloanDivision of Early Detection and Prevention, Translational Genomics Research Institute, TGen, Phoenix, AZ.ORCID https://orcid.org/0009-0008-5619-9270
Anna BonfittoDivision of Early Detection and Prevention, Translational Genomics Research Institute, TGen, Phoenix, AZ.ORCID https://orcid.org/0009-0001-5796-5167
Bobbi StarkDivision of Early Detection and Prevention, Translational Genomics Research Institute, TGen, Phoenix, AZ.ORCID https://orcid.org/0009-0006-6083-8675
Serena SongDivision of Early Detection and Prevention, Translational Genomics Research Institute, TGen, Phoenix, AZ.ORCID https://orcid.org/0009-0008-4039-6704
Marcus NaymikDivision of Early Detection and Prevention, Translational Genomics Research Institute, TGen, Phoenix, AZ.ORCID https://orcid.org/0009-0007-7727-8851
Changiz GeulaMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, IL; and.ORCID https://orcid.org/0000-0002-9311-3295
Tamar GefenMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, IL; and.ORCID https://orcid.org/0000-0002-2380-3100
Elena BarbieriMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, IL; and.ORCID https://orcid.org/0000-0002-7303-846X
Ignazio PirasDivision of Early Detection and Prevention, Translational Genomics Research Institute, TGen, Phoenix, AZ.ORCID https://orcid.org/0000-0003-4024-3368
M-Marsel MesulamMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, IL; and.ORCID https://orcid.org/0000-0001-5731-851X
Matthew HuentelmanDivision of Early Detection and Prevention, Translational Genomics Research Institute, TGen, Phoenix, AZ.ORCID https://orcid.org/0000-0001-7390-9918

Funding

Neuropathology CoreP30AG013854 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI VASSAR, ROBERT J · 1996 to 2020
$28.9M
Research Education Core FP30AG072977 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR · 2021 to 2026
$26.3M
ASYMMETRIC NEURODEGENERATION AND LANGUAGE IN PRIMARY PROGRESSIVE APHASIAR01AG077444 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MAREK-MARSEL M MESULAM, EMILY J ROGALSKI · 2022 to 2026
$10.4M
Clinical, Neuroanatomic, and Pathologic Signatures of FTLD-tau in Dementia Phenotypes - Diversity Supplement (Antwan Howard)R01AG062566 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEFEN, TAMAR D · 2020 to 2024
$2.1M
Anatomic, Pathologic, and Molecular Signatures of FTLD-TDP type CR01AG091388 · NIA · NORTHWESTERN UNIVERSITY · PI CHANGIZ GEULA, Tamar D Gefen · 2025 to 2026
$1.6M
NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG072977NIA NIH HHS R01 AG062566NIA NIH HHS R01 AG077444NIA NIH HHS R01 AG091388
6 · The paper itself

Abstract

Background and Objectives: Frontotemporal lobar degeneration TDP43 type C (TDP-C) is a rare and unique neurodegenerative disease that attacks the anterior temporal lobe. Recently, it was shown that Annexin-A11 and TDP-43 coaggregate specifically in TDP-C. Current literature on the genetic associations with TDP-C, reviewed here, lacks a discernible corpus of robust or replicated findings. In this study, using blood tissue, we completed whole genome sequencing to investigate Methods: (1) We tested common variants in Results: (1) Four common variants in Discussion: This study provides replicated evidence for the association between common variants in

Identifiers

PMID41883703
PMCPMC13010282

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.