Evidence map›Paper›PMID 41883506›Full record

ArticleFrontiers in pharmacology2026

Khalil Ben Hassine, Shannon Robin, Frederic Baleydier, Mourad Mseddi, Vid Mlakar, Jayaraman Muthukumaran, Marc Ansari, Chakradhara Rao Satyanarayana Uppugunduri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Khalil Ben Hassine *Cansearch Research Platform for Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland.
Shannon Robin *Cansearch Research Platform for Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland.
Frederic BaleydierCansearch Research Platform for Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland.
Mourad MseddiCansearch Research Platform for Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland.
Vid MlakarCansearch Research Platform for Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland.
Jayaraman MuthukumaranDepartment of Biotechnology, Sharda School of Bio-Science and Technology, Sharda University, Greater Noida, India.
Marc Ansari *Cansearch Research Platform for Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland.
Chakradhara Rao Satyanarayana Uppugunduri *Cansearch Research Platform for Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Understanding drug interactions in hematopoietic stem cell transplantation (HSCT) is crucial given the narrow therapeutic index of busulfan (BU), which is a key conditioning agent. In this study, we investigate the potential impacts of fludarabine (Flu) as a frequently co-administered agent in HSCT on BU pharmacokinetics (PK). Specifically, we examine whether Flu can alter BU metabolism by affecting the predominantly expressed cytosolic glutathione-S-transferases (GSTs), particularly GSTA1, GSTM1, and GSTP1, which are essential for BU detoxification. Methods: We conducted molecular docking and atomistic molecular dynamics simulations using the crystal structures of GSTA1, GSTM1, and GSTP1 to study the estimated binding affinity of Flu as well as its metabolites to these target enzymes. We then performed Results: Conclusion: The present study underscores the importance of empirically validating

Indexed as

drug–drug interactionenzyme inhibitionenzyme kineticsestimated binding affinityglutathione-S-transferase enzymemolecular dockingmolecular dynamics simulation

Identifiers

PMID41883506
PMCPMC13010162

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.