ArticleJournal of tissue engineering
Evaluating the electrical stimulation of bone cells based on an induced transmembrane potential model and intracellular calcium levels.
Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Electrical stimulation holds promise for enhancing bone healing; however, it has not yet seen widespread clinical adoption. A significant obstacle is the limited understanding of the biological mechanisms involved and the electric field parameters required to trigger them. It has been observed that the intracellular calcium ion concentration increases upon electrical stimulation, possibly via the activation of voltage-gated calcium channels. In this work, we introduced a digital twin framework to rationally choose stimulation parameters. We aimed to induce a transmembrane potential sufficient to activate the voltage-gated calcium channels. We focused on kilohertz-frequency stimulation, which offers advantages for clinical translation, and applied electrical stimuli using a well-established direct-contact stimulation chamber. By combining this with live-cell calcium imaging, we observed the immediate stimulation effect. We found that a stimulation at
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