Evidence map›Paper›PMID 41883474›Full record

ArticleBiofilm2026

Mapping the global landscape of biofilm-associated antimicrobial resistance (1992-2025).

Caixia Tan, Jie Wang, Anhua Wu, Chunhui Li

Abstract read
In one paragraph

Article in Biofilm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Caixia TanInfection Control Center, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Jie WangInfection Control Center, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Anhua WuInfection Control Center, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Chunhui LiInfection Control Center, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance (AMR) is a great global health threat, with biofilm formation recognized as a key microbial survival strategy that promotes persistence and recurrent infections. Despite growing mechanistic insights, research on biofilm-associated AMR ((biofilm-AMR)) remains fragmented, limiting the development of broadly effective interventions. To address this gap, we conducted a bibliometric analysis of 17,198 publications from the Web of Science Core Collection (retrieved November 4, 2025) using Bibliometrix-Biblioshiny, CiteSpace, and Excel. Publication output accelerated sharply after 2015, alongside diversification of research themes and increasing interdisciplinary integration. High-output countries and institutions, predominantly in Asia, Latin America, and the Middle East, emphasize natural products, nanomaterials, anti-quorum-sensing strategies, and plant-derived antimicrobials, reflecting application-oriented approaches. In contrast, high-impact contributors in North America and Europe focus on clinical microbiology, resistance mechanisms, pathogen genomics, and hospital infection control, highlighting translational relevance. Trend analyses reveal key topics including quorum sensing, persister-cell biology, multidrug-resistant pathogens, and innovative interventions such as phage therapy, antimicrobial peptides, CRISPR-based antimicrobials, and nanotechnology-enabled drug delivery. Emerging directions include environmental AMR, One Health perspectives, and computational modeling. Despite mechanistic and technological advances, translational barriers persist due to biofilm heterogeneity and model limitations. Promoting interdisciplinary collaboration that integrates basic research, clinical microbiology, materials science, and computational approaches will be essential to accelerate clinical translation and develop effective, globally relevant strategies against AMR.

Indexed as

Anti-biofilm therapeuticsAntimicrobial resistance (AMR)Bibliometric analysisBiofilmGlobal health

Identifiers

PMID41883474
PMCPMC13010984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.