Evidence map›Paper›PMID 41883470›Full record

ReviewInternational journal of general medicine2026

Discovering the Molecular Secrets of Traditional Chinese Medicine: An Interpretation of Herbal Therapeutics Using Systems Biology.

Haitao Zhang, Xudong Zhuang, Aizhu Lin, Chunquan Zhou, Wenzeng Wei, Xinrui Wang, Gong Wang

Abstract readReview
In one paragraph

Review in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haitao ZhangDepartment of Medical Research Center, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, People's Republic of China.
Xudong ZhuangDepartment of Medical Research Center, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, People's Republic of China.
Aizhu LinDepartment of Medical Research Center, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, People's Republic of China.
Chunquan ZhouDepartment of Technology Products Research and Development Center, Fujian Academy of Chinese Medical Sciences, Fuzhou, People's Republic of China.
Wenzeng WeiDepartment of Technology Products Research and Development Center, Fujian Academy of Chinese Medical Sciences, Fuzhou, People's Republic of China.
Xinrui WangDepartment of Medical Research Center, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, People's Republic of China.
Gong WangDepartment of Technology Products Research and Development Center, Fujian Academy of Chinese Medical Sciences, Fuzhou, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systems biology is primarily concerned with the dynamic study of biochemical metabolic processes in physical systems, the interplay of multiple signal transduction routes, gene regulatory networks, and disease causes, among other things. Its most notable aspect is that it merges individual genes with protein studies into thousands of genes or proteins, resulting in "three-dimensional" research. The action advantage of Traditional Chinese Medicine (TCM) is in the integration and modulation of the impact of each individual medication. TCM active components are compatible and blended according to specified conditions, and the integrated medication action is characterized by multi-target and multi-way integration, which is consistent with system biology research theories. Actively introducing new concepts and approaches, such as system biology, will most likely lead to a breakthrough in advancing TCM modernization. This paper aims to review the application of systems biology technologies in TCM research, with a focus on unraveling the multi-component synergistic mechanisms, deciphering the molecular network regulatory patterns, and evaluating the safety and toxicity of TCM compounds, thereby illuminating the molecular basis of TCM's efficacy in improving complex diseases such as cardiovascular disease and cancer. By adopting the "three-dimensional" research framework of systems biology, this work intends to furnish advanced application references for the holistic view research strategy of Chinese medicine, thereby bridging the systemic research paradigm with traditional TCM theoretical frameworks.

Indexed as

genomicsmetabolomicsmicrobiomicsomics technologiesproteomicssystems biologytraditional Chinese medicine

Identifiers

PMID41883470
PMCPMC13012537

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.