ArticleInternational journal of general medicine2026
Clinicopathological Features and Survival Prognosis of Subcutaneous Panniculitis-Like T-Cell Lymphoma: A Population-Based Study from the SEER Database with Supplementary Single-Center Case Validation.
Article in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a rare entity which primarily involved skin and subcutaneous tissue, with clinicopathological features similar to subcutaneous panniculitis. The etiology, clinical features, clinical outcomes and prognostic factors remain largely unknown. Methods: To gain insight into this distinct entity, we summarized the clinicopathologic features of 8 unpublished SPTCL cases and performed a comprehensive analysis based on SEER (Surveillance, Epidemiology, and End Results) database. Results: Clinically, subcutaneous nodules with no tenderness appeared firstly in seven patients, and cough in one patient. Hemophagocytic syndrome developed in 3 patients. The median progression-free survival (PFS) for the whole cohort was 43 months, while the median overall survival (OS) has not reached. We identified a cohort of 210 SPTCL patients between 2000 and 2020 based on SEER database. Over half of patients had B symptoms (56.2%) and present at advanced stage (55.6%). The 5-year overall survival (OS) rate was 77.6% for the whole cohort. Multivariate analysis showed that age >60 years and diagnosis before the year 2008 were important prognostic factors of OS for SPTCL. Conclusion: Our results identified the clinical characteristics, OS and prognostic factors of a large cohort of SPTCL.
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