Evidence map›Paper›PMID 41883445›Full record

ReviewWorld journal of experimental medicine2026

Unconventional mechanisms of resveratrol in atherosclerosis prevention and management.

Nadim Chaarani, Riyad Mroweh, Razan Moghnieh, Mohammad Kheir Chahine, Hassan Zaiter, Saleh-Yezan Abdulaal, Nazih Obeid, Mohamad Tlais, Joy Raheb, Hadi Farhat and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nadim ChaaraniFaculty of Medicine and Medical Sciences, University of Balamand, Beirut 1100, Dekwaneh, Lebanon.
Riyad MrowehFaculty of Medicine and Medical Sciences, University of Balamand, Beirut 1100, Dekwaneh, Lebanon.
Razan MoghniehFaculty of Medicine and Medical Sciences, University of Balamand, Beirut 1100, Dekwaneh, Lebanon.
Mohammad Kheir ChahineFaculty of Medicine and Medical Sciences, University of Balamand, Beirut 1100, Dekwaneh, Lebanon.
Hassan ZaiterFaculty of Medicine and Medical Sciences, Lebanese American University, Beirut 1100, Dekwaneh, Lebanon.
Saleh-Yezan AbdulaalDepartment of Internal Medicine, Stadtkrankenhaus Korbach, Korbach 34497, Germany.
Nazih ObeidFaculty of Medicine and Medical Sciences, University of Balamand, Beirut 1100, Dekwaneh, Lebanon.
Mohamad TlaisFaculty of Medicine and Medical Sciences, University of Balamand, Beirut 1100, Dekwaneh, Lebanon. mmtlaiss22@gmail.com.
Joy RahebDepartment of Internal Medicine, Cleveland Clinic, Cleveland, OH 44101, United States.
Hadi FarhatFaculty of Medicine and Medical Sciences, University of Balamand, Beirut 1100, Dekwaneh, Lebanon.
Razan AbdulaalFaculty of Medicine and Medical Sciences, University of Balamand, Beirut 1100, Dekwaneh, Lebanon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis is a progressive inflammatory disease and a major contributor to cardiovascular disease. Resveratrol (RES), a polyphenolic compound found in grapes and red wine, has been widely investigated for its protective effects on cardiovascular health. This review summarizes the mechanisms through which RES attenuates atherosclerosis, including its anti-inflammatory, antioxidant, and lipid-modulating effects. Experimental evidence indicates that RES inhibits nuclear factor kappa-light-chain-enhancer of activated B cells signaling, thereby reducing the expression of adhesion molecules such as vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and limiting immune cell infiltration into the arterial wall. Additionally, it counteracts oxidative stress by enhancing antioxidant enzyme activity and preventing low-density lipoprotein oxidation, a key event in foam cell formation. RES also promotes cholesterol efflux through adenosine triphosphate-binding cassette transporters, supporting high-density lipoprotein-mediated reverse cholesterol transport. Findings from

Indexed as

AtherosclerosisEndothelial dysfunctionFoam cellsGut microbiotaInflammationResveratrol

Identifiers

PMID41883445
PMCPMC13010497

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.