Evidence map›Paper›PMID 41883444›Full record

ArticleWorld journal of experimental medicine2026

Diagnostic utility of circulating interleukin-1 beta and microRNA-146a in differentiating febrile seizures from other pediatric conditions.

Saeed Mohammadi, Mwssa Abbood Hameed Ati, Fakhri Sadat Seyedhosseini, Mojtaba Zare Ebrahimabad, Mohsen Saeidi, Seyed Ahmad Hosseini, Mahmoud Darweesh, Ahmed Al-Harrasi, Yaghoub Yazdani

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Article in World journal of experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Saeed MohammadiNatural and Medical Sciences Research Center, University of Nizwa, Nizwa 616, Ad Dakhiliyah, Oman.
Mwssa Abbood Hameed AtiDepartment of Immunology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan 4934174515, Golestān, Iran.
Fakhri Sadat SeyedhosseiniDepartment of Internal Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan 4934174515, Golestān, Iran.
Mojtaba Zare EbrahimabadMetabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan 4934174515, Golestān, Iran.
Mohsen SaeidiStem Cell Research Center, Golestan University of Medical Sciences, Gorgan 4934174515, Golestān, Iran.
Seyed Ahmad HosseiniDepartment of Pediatrics, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan 4934174515, Golestān, Iran.
Mahmoud DarweeshNatural and Medical Sciences Research Center, University of Nizwa, Nizwa 616, Ad Dakhiliyah, Oman.
Ahmed Al-HarrasiNatural and Medical Sciences Research Center, University of Nizwa, Nizwa 616, Ad Dakhiliyah, Oman.
Yaghoub YazdaniLaboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan 4934174515, Golestān, Iran. yazdani@goums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFebrile seizures (FS) are common pediatric neurological disorders typically triggered by fever, affecting children aged 6 months to 5 years. Although usually benign, early and accurate diagnosis is crucial for effective management.

aimTo investigate the diagnostic potential of interleukin-1 beta (IL-1β) and microRNA-146a (miR-146a) in distinguishing FS from healthy subjects (HS), fever-only (FO), and seizure-only (SO) cases.

methodsPediatric patients were grouped into FS (

resultsIL-1β levels showed the highest level in FS, followed by FO and SO, with HS showing the lowest levels. IL-1β distinguished FS from HS with an area under the curve (AUC) of 0.9983 (sensitivity: 100%, specificity: 96.15%). miR-146a was lowest in FS and highest in HS, achieving an AUC of 1.000 (sensitivity: 100%, specificity: 98.08%). IL-1β and miR-146a also effectively differentiated FS from FO and SO, with respective AUCs of 0.8862 and 0.8173 for FS

conclusionIL-1β and miR-146a could be promising diagnostic biomarkers for FS, distinguishing FS from HS, FO, and SO with high sensitivity and specificity. These markers possess the potential to enhance early FS diagnosis.

Indexed as

BiomarkersDiagnostic utilityFebrile seizureFever-onlyHealthy subjectsInterleukin-1 betaMicroRNA-146aSeizure-only

Identifiers

PMID41883444
PMCPMC13010478

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