ArticleWorld journal of experimental medicine2026
Differences of immunohistochemical profiling of MOC-31, caveolin-1, connexin-43, Ki-67 in ameloblastic fibroma, ameloblastic fibrodentinoma, ameloblastic fibro-odontoma, and odontomas.
Article in World journal of experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundOdontogenic tumors are a heterogeneous group of lesions originating from tissues involved in odontogenesis. Mixed odontogenic tumors comprise a group of lesions characterized by the presence of ectodermal and mesenchymal odontogenic tissues with or without the formation of hard dental tissues.
aimTo determine and compare the expression of caveolin-1, MOC-31, connexin-43 (Cx-43), and Ki-67 in ameloblastic fibromas (AF), ameloblastic fibrodentinomas (AFD), ameloblastic fibro-odontomas (AFO), and odontomas (O).
methodsImmunohistochemical analysis for caveolin-1, MOC-31, Cx-43, and Ki-67 was performed on eight AF, one AFD, five AFO, and six O.
resultsVariable protein expression was identified in the epithelium and mesenchyme of most AF, AFD, and AFO with lower expression observed in O. Immunohistochemical analysis revealed significant differences in protein expression between AF and O (
conclusionThis immunohistochemical study suggested that the similarity in protein expression between AFD, AFO, and AF compared with O may be due to the biological proximity among these lesions at the protein expression level. Further studies with larger sample sizes and complementary techniques are required to validate these findings.
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