Trial reportWorld journal of experimental medicine2026
Indocyanine green doped with chitosan nanoparticles based antimicrobial photodynamic therapy in periodontitis patients: A randomized clinical trial.
Trial report in World journal of experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPeriodontitis is a chronic inflammatory disease triggered by a polymicrobial challenge to the periodontium. While scaling and root planing (SRP) is the gold standard for treatment, its efficacy is often limited by incomplete pathogen eradication and rising antimicrobial resistance. Antimicrobial photodynamic therapy (aPDT) has emerged as a potent adjunctive treatment, utilizing light-activated photosensitizers to induce targeted bacterial lysis. Specifically, the delivery of indocyanine green (ICG)
aimTo evaluate the overall improvements in various clinical and microbiological periodontal parameters in periodontitis patients undergoing aPDT with CNPs-ICG.
methodsThirty periodontitis patients having interdental clinical attachment loss (CAL) 'detectable' at ≥ 2 non-adjacent teeth, buccal or oral CAL ≥ 3 mm with pocketing > 3 mm detectable at ≥ 2 teeth were randomly assigned to aPDT with CNPs-ICG + SRP (test) group and conventional SRP + laser irradiation only (control) group in a split-mouth design. At baseline, 1-month and 3-months plaque index (PI), modified sulcular bleeding index, pocket probing depth (PPD) and relative clinical attachment level (RCAL) and microbiological tests were recorded.
resultsThe test group showed more improvement in PPD (7 mm to 3.26 mm in 1-month and 3.13 mm in 3-months) and RCAL (12 mm to 8.26 mm in 1 month and 8.4 mm in 3 months) than control group that showed PPD reduction from 6.7 mm (at baseline) to 3.73 mm at 1-month and 3.76 mm at 3 months and RCAL reduction from 12.23 mm (at baseline) to 8.7 mm at 1-month and 8.9 mm at 3-months with a statistically significant difference (
conclusionaPDT using CNPs-ICG + SRP can be considered as a better procedure in improving periodontal clinical parameters like PPD and RCAL and in reducing periodontal pathogens than conventional SRP alone.
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