Evidence map›Paper›PMID 41883432›Full record

ArticleProceedings. IEEE International Conference on Micro Electro Mechanical Systems2026

CMOS-EMBEDDED MICROFLUIDICS FOR CHANNEL-ADDRESSABLE PARALLEL READOUT OF SPAD FLUORESCENCE LIFETIME SENSORS.

Max S Ladabaum, Alexander Di, Julian M Bao, Grigory Tikhomirov, Jun-Chau Chien

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings. IEEE International Conference on Micro Electro Mechanical Systems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Max S LadabaumUniversity of California, Berkeley.
Alexander DiUniversity of California, Berkeley.
Julian M BaoUniversity of California, Berkeley.
Grigory TikhomirovUniversity of California, Berkeley.
Jun-Chau ChienUniversity of California, Berkeley.

Funding

A CMOS-based miniaturized and disposable molecular detection system enabling sample in-situ biosensingR01EB038309 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHIEN, JUN-CHAU · 2025 to 2025
$2.3M
SEMI-SIMOA: A Chip-scale Flow-based Single-Molecule Assay at the Point-of-Care using Semiconductor TechnologyR21EB036154 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI Jun-Chau Chien · 2024 to 2026
$475k
NIBIB NIH HHS R01 EB038309NIBIB NIH HHS R21 EB036154
6 · The paper itself

Abstract

We present the integration of CMOS-embedded subtractive microfluidics with single-photon avalanche diode (SPAD) fluorescence lifetime sensors, enabling independent channel addressability for parallel readout. Microfluidic channels are realized by selectively wet-etching the back-end-of-line (BEOL) metal routing above the SPAD sensors, reducing the analyte-to-active-region spacing to 7 μm while allowing for precision alignment. Simultaneous readout from two SPADs underneath two separate fluidic channels is demonstrated, establishing a pathway toward a scalable, multiplexed lab-on-CMOS biosensing platform.

Indexed as

BiosensorCMOSFluorescence lifetimeLab-on-ChipSPADSubtractive microfluidicsTCSPC

Identifiers

PMID41883432
PMCPMC13010990

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.