ArticleFrontiers in nutrition2026
Cannabis oil modulates liver alterations and endocannabinoid system changes in a female rat model of diet-induced MASLD.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Sustainable Extraction of Bioactive Phenolic Compounds from Cannabis Leaf Powder from Local Strain of Tucumán, Argentina, to Promote a Circular Economy.Molecules (Basel, Switzerland) · 2026Article
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8 authors.
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Abstract
Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely linked to alterations in liver lipid metabolism, oxidative stress, fibrosis, and dysregulation of the endocannabinoid system (ECS). Although increasing evidence supports a role for cannabinoids in metabolic disorders, most preclinical studies have been conducted in male models, leaving female-specific responses largely unexplored. Methods: This study evaluated the effects of oral administration of a full-spectrum cannabis oil (CBD:THC 2:1) on MASLD-related alterations and ECS regulation in female Wistar rats fed a sucrose-rich diet (SRD). Rats were assigned to reference diet (RD), SRD, or SRD plus cannabis oil (1 mg/kg/day) for 3 weeks. Results: SRD-fed rats developed liver steatosis and increased NAFLD activity score (NAS), accompanied by enhanced Discussion: These findings demonstrate that full-spectrum cannabis oil is associated with improved MASLD-related outcomes and modulation of ECS tone in a female-specific model of diet-induced metabolic liver disease.
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