ArticleFrontiers in nutrition2026
Adipose tissue protein profiling: modulation by vitamin D receptor.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Phase angle as a potential marker of early nutritional and metabolic changes following metabolic bariatric surgery: a retrospective study.Frontiers in nutrition · 2026Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Little is known regarding the expression patterns of adipose tissue proteins in the context of vitamin D deficiency and whether these expression patterns have adverse effects on fat-related diseases. Methods: This study compares vitamin D receptor-knockout (VDRKO) and wild-type (WT) mice to determine whether the VDRKO affects the adipose tissue landscape. High-throughput proteomic technology and parallel reaction monitoring-based targeted proteomics were utilized to determine and verify protein level changes. Results: Integrated proteomic and succinylomic analyses revealed that VDR deletion profoundly reprograms the adipose tissue molecular landscape. We identified 572 differentially expressed proteins and 313 differentially succinylated proteins. In VDRKO mice, protein levels involved in biological regulation, metabolic processes, ribosome, and endoplasmic reticulum protein processing pathways were upregulated. Conversely, proteins serving as negative regulators were enriched in pathways such as complement and coagulation cascades and protein digestion and absorption. Notably, ribosomal proteins (e.g., pancreatic alpha-amylase: Amy2 and proliferation-associated protein 2G4:Pa2g4) were significantly upregulated, while collagen proteins (e.g., Col24a1, Col6a4) were identified as key downregulated regulators in the protein digestion and absorption pathway. Succinylome analysis further indicated extensive succinylation modifications on proteins associated with energy metabolism pathways, including alanine, aspartate and glutamate metabolism, and arginine biosynthesis. These modifications were prominent not only in mitochondria but also in the cytoplasm, suggesting a broad regulatory role for succinylation beyond mitochondrial metabolism in the VDR-deficient state. Conclusion: This integrated multi-omics study provides the first comprehensive proteomic and succinylomic profile of VDRKO adipose tissue, revealing succinylation as a novel regulatory layer in energy metabolism. Our findings advance the understanding of vitamin D signaling in adipose biology and highlight potential therapeutic targets for metabolic disorders.
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