ArticleOpen life sciences2025
A multiplicative behavioral model of DNA replication initiation in cells.
Article in Open life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
DNA replication is a precisely timed cellular decision rather than a continuous biochemical process. Despite extensive mechanistic detail, no unified framework quantitatively explains how structural, metabolic, chromatin, and phase-dependent factors converge to initiate replication. Here, we introduce the ARCH × Φ model, which defines replication onset as a multiplicative threshold event integrating structural, metabolic, chromatin, and phase-control domains. Derived from the recently formalized ARCH behavioral framework, the model expresses replication initiation as
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