ReviewOpen life sciences2025
Histone modification and non-coding RNAs in skin aging: emerging therapeutic avenues.
Review in Open life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Epigenetic pacemaker: A review of DNA methylation, histone lactylation, and non-coding RNAs in autoimmune skin diseases.Journal of translational autoimmunity · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin aging is a lifelong process that begins after birth and is characterized by a decline in morphology and function. This deterioration is associated with the appearance of wrinkles, increased laxity, and fragility, which may increase the risk of age-related skin diseases. Despite extensive research in the past few decades, the underlying mechanism of skin aging remains unknown. Epigenetic modifications, which refer to potentially heritable alterations without changes in DNA sequence, including DNA methylation, histone modification, and non-coding RNAs (ncRNAs), have been implicated in regulating skin aging through intrinsic and extrinsic interactions. In this review, we summarize the available clinical and experimental studies to elucidate the mechanisms of epigenetic regulation in skin aging, with a focus on DNA methylation, histone modification, and ncRNAs (such as miRNA, lncRNA, and circRNA). Epigenetic inheritance has been shown to regulate the senescence and collagen synthesis of skin cells, which can interfere with skin aging. Therefore, this review highlights the molecular mechanisms underlying skin aging and potential therapeutic targets for intervention, while also identifying directions for reversing skin aging.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.