ArticleOpen life sciences2025
Dissecting the molecular mechanisms of T cell infiltration in psoriatic lesions
Article in Open life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to elucidate the intercellular communication mechanisms underlying T cell infiltration in psoriatic skin. Single-cell RNA sequencing revealed increased proportions of endothelial cells and T cells, alongside a reduction in melanocytes in psoriatic skin. Pseudotime analysis demonstrated dynamic transitions in T cell states, with significant gene expression changes at key branching points. These genes were enriched in pathways related to the ribosome, cytoplasmic translation, and ribosomal structural components. Cell-cell communication analysis showed enhanced interactions, particularly between T cells and fibroblasts in psoriasis. Fibroblasts exhibited upregulated MK signaling, characterized by elevated MDK expression and increased MDK receptor levels on T cells, suggesting MDK-mediated T cell recruitment. Regulatory network analysis identified IL-6 as a primary ligand regulating MDK
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.