Evidence map›Paper›PMID 41883347›Full record

ArticleRegenerative biomaterials2026

Ultrasound-activated UiO-66 enables ROS-mediated antibacterial therapy and accelerates diabetic wound healing.

Chuanwei Sun, Gaoquan Zheng, Yingying Zhao, Zuan Liu, Zhihui Jiang, Jiongliang Li, Chongquan Huang, Yuan Yan, Wen Lai, Zhifeng Huang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. ROS-Balancing MXene/MoSeSmall (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chuanwei SunDepartment of Orthopaedics Oncology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510080, China.
Gaoquan ZhengSchool of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
Yingying ZhaoDepartment of Gastroenterology, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, Guangdong 511400, China.
Zuan LiuDepartment of Burns and Wound Repair Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510080, China.
Zhihui JiangDepartment of Pharmacy, General Hospital of Southern Theatre Command, Guangzhou 510010, China.
Jiongliang LiMedical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
Chongquan HuangMedical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
Yuan YanMedical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
Wen LaiDepartment of Burns and Wound Repair Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510080, China.
Zhifeng HuangDepartment of Burns and Wound Repair Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510080, China.
Lidan LiuDepartment of Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Feng PengGuangdong Engineering Technology Research Center of functional repair of bone defects and biomaterials, Guangzhou, Guangdong 510080, China.ORCID https://orcid.org/0000-0003-2366-2253
Yu ZhangDepartment of Orthopaedics Oncology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510080, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of noninvasive and dual-functional therapeutic strategies is of critical importance for the treatment of infected diabetic wounds, which require both effective bacterial eradication and enhanced tissue regeneration. Conventional approaches are frequently constrained by single-function modalities or adverse side effects, emphasizing the demand for safer and more versatile alternatives. In this study, we demonstrate for the first time that pristine UiO-66, a metal-organic framework without surface modification, can serve as a novel nanoplatform for sonodynamic therapy (SDT), simultaneously achieving antibacterial and pro-regenerative effects. Comprehensive structural and photochemical analyses reveal that UiO-66 efficiently generates reactive oxygen species (ROS) under ultrasound irradiation, which endow it with broad-spectrum antibacterial capacity. These effects are validated by

Indexed as

diabetic wound healingmetal-organic frameworksreactive oxygen speciessonodynamic therapy

Identifiers

PMID41883347
PMCPMC13012228

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.