ArticleJournal of clinical periodontology2026
Traumatic Occlusion Exacerbates Bone Resorption by Modifying Gene Expression in the Bone Tissue of Ligature-Induced Periodontitis in Mice.
Article in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimTo clarify the molecular mechanisms of occlusal trauma in bone loss through periodontal tissue transcriptome analysis in mice with periodontitis and traumatic occlusion. MATERIALS AND
methodsLigature-induced periodontitis (Li) and composite resin-induced traumatic occlusion (Tra) mouse models were established (control [Co], Li, Tra and LiTra). Bone resorption was evaluated using micro-computed tomography (micro-CT). RNA-sequencing was conducted on gingiva, bone and periodontal ligament from all groups 3 days post induction. For long-term evaluation, the Co and Tra groups were maintained for 8 weeks and then analysed using micro-CT and qRT-PCR.
resultsTraumatic occlusion alone, sustained for 8 weeks, did not directly induce bone resorption; however, it significantly exacerbated bone resorption in mice with periodontitis. Cytokine-cytokine receptor interactions and Toll-like receptor signalling pathways were up-regulated in LiTra bone tissue. Il11, Il1rl1 and Mmp3, associated with inflammation and bone metabolism, were more highly expressed in the LiTra group than in the Li group. TNF-α signalling via NFκB and inflammatory response gene sets were enriched in the bone tissue of LiTra group.
conclusionsTraumatic occlusion accelerates bone resorption in ligature-induced periodontitis but does not independently cause significant bone loss. Occlusal trauma enhances the expression of inflammation-related genes, especially in bone with periodontitis.
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