ArticleACS nano2026
Emergence of Anisotropic Subcompartments via Coassembly of Hierarchically Ordered G-Quadruplexes and Fluid Polylysine in Droplet-Based Compartments.
Article in ACS nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Liquid-liquid phase separation (LLPS) plays a key role in cellular organization, enabling the formation of dynamic compartments that provide spatial and temporal control over biochemical processes. Although LLPS systems are typically fluidic, recent studies have revealed that specific molecular constituents can induce an internal structure. Here, we show that droplet formation between guanine quadruplexes (G4s) and polylysine peptides triggers G4-driven internal structural ordering. Using birefringence-retardation imaging, confocal fluorescence imaging, as well as X-ray diffraction and scattering techniques, we demonstrate that anisotropic subcompartments are gradually developed at specific points of their droplet-solution interfaces. The G4s possess intrinsic molecular rigidity due to their stacked G-quartet structures, and their interaction with the flexible polylysine peptides enables the formation of a hexagonal columnar phase (
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