Evidence map›Paper›PMID 41883042›Full record

ArticleLymphatic research and biology2026

Tissue Sodium Response to Complete Decongestive Therapy in Lower Extremity Lymphedema.

Shannon L Taylor, Vanessa N Crain, Paula M C Donahue, Sheau-Chiann Chen, Michael D Pridmore, Maria E Garza, John A Beasley, Miracle P Darrington, Allison O Scott, Cheyenne N Whaley and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lymphatic research and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shannon L TaylorDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Vanessa N CrainVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Paula M C DonahuePhysical Medicine & Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sheau-Chiann ChenDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Michael D PridmoreVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Maria E GarzaDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
John A BeasleyVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Miracle P DarringtonVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Allison O ScottVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Cheyenne N WhaleyVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Yu LuoDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Alaina J BrownDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Rachelle L CrescenziDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA.

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Visualizing vascular mechanisms of lipedemaR01HL157378 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CRESCENZI, RACHELLE L · 2021 to 2025
$2.5M
Imaging sodium and lymphatics in lymphedemaR01HL155523 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CRESCENZI, RACHELLE L · 2021 to 2025
$2.4M
Replacement and Upgrade of a 3T MR Scanner for ResearchS10OD021771 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GORE, JOHN C · 2016 to 2016
$2.0M
NCATS NIH HHS UL1 TR000445NHLBI NIH HHS R01 HL155523NHLBI NIH HHS R01 HL157378NIH HHS S10 OD021771
6 · The paper itself

Abstract

backgroundLower extremity lymphedema affects a growing number of cancer survivors. Standard-of-care therapy for lymphedema is complete decongestive therapy (CDT), yet the primary outcome measurement of therapeutic efficacy is limb volume, which is relatively insensitive to both well-managed and severe disease. The primary goal of this study was to examine whether physiological sodium magnetic resonance imaging ( METHODS AND

resultsParticipants with lymphedema (

conclusionsTSC is reduced in the skin of affected legs with lymphedema treated by CDT, which is observable within the reproducibility limits of

Indexed as

Lower ExtremityLymphedemaSodiumAdipose TissueAdultAgedFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedReproducibility of ResultsSkinTreatment OutcomeSodiumadipose tissuecomplete decongestive therapylymphedemamagnetic resonance imagingtissue sodium

Identifiers

PMID41883042
PMCPMC13474578

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.