Evidence map›Paper›PMID 41883041›Full record

ArticleCannabis and cannabinoid research2026

Associations Between Cannabis Use and Inflammatory Biomarkers Among People with HIV.

Stephanie A Ruderman, Joseph A C Delaney, Kristina A Crothers, Engi F Attia, Bridget M Whitney, Sonia Napravnik, Laura Bamford, Michael S Saag, Richard D Moore, Kenneth H Mayer and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cannabis and cannabinoid research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Stephanie A RudermanUniversity of Washington, Seattle, Washington, USA.ORCID 0000-0002-0058-5729
Joseph A C DelaneyUniversity of Washington, Seattle, Washington, USA.
Kristina A CrothersUniversity of Washington, Seattle, Washington, USA.
Engi F AttiaUniversity of Washington, Seattle, Washington, USA.
Bridget M WhitneyUniversity of Washington, Seattle, Washington, USA.
Sonia NapravnikUniversity of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Laura BamfordUniversity of California San Diego, San Diego, California, USA.
Michael S SaagUniversity of Alabama at Birmingham, Birmingham, Alabama, USA.
Richard D MooreJohns Hopkins University, Baltimore, Maryland, USA.
Kenneth H MayerHarvard Medical School, Fenway Institute, Boston, Massachusetts, USA.
Inga PeterIcahn School of Medicine at Mount Sinai, New York, New York, USA.
Amelia DeitchmanUniversity of California San Francisco, San Francisco, California, USA.
Carl GrunfeldUniversity of California San Francisco, San Francisco, California, USA.
Fang FangResearch Triangle Institute, Research Triangle Park, North Carolina, USA.
Mari M KitahataUniversity of Washington, Seattle, Washington, USA.
Heidi M CraneUniversity of Washington, Seattle, Washington, USA.
Peter W HuntUniversity of California San Francisco, San Francisco, California, USA.

Funding

Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
Substance use patterns and contexts: impact on epigenetic age and prevention strategies in an HIV clinical care cohortR01DA047045 · NIDA · UNIVERSITY OF WASHINGTON · PI Heidi M. Crane, Joseph Austin Delaney · 2018 to 2026
$5.1M
Links between Cardiovascular disease, Lung disease, and Obstructive sleep apnea in HIV: Understanding complex patientsR01HL126538 · NHLBI · UNIVERSITY OF WASHINGTON · PI CRANE, HEIDI M., CROTHERS, KRISTINA ANNE · 2015 to 2025
$5.1M
Persistent Functional Immune Defects in Treated HIV InfectionK24AI145806 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUNT, PETER W · 2020 to 2024
$921k
Plasma Proteomic and Metabolomic Predictors of Vascular Disease in Treated HIVR56HL160457 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUNT, PETER W · 2021 to 2021
$789k
NHLBI NIH HHS R01 HL126538NHLBI NIH HHS R56 HL160457NIAID NIH HHS K24 AI145806NIAID NIH HHS R24 AI067039NIDA NIH HHS R01 DA047045
6 · The paper itself

Abstract

backgroundWe explored whether self-reported current cannabis use is associated with inflammatory biomarkers among people with HIV (PWH), given high rates of cannabis use and chronic immune activation among PWH.

methodsAt seven Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort sites, which integrate data on participant characteristics including demographic and clinical information, and substance use behaviors, we used linear regression to estimate the average difference in biomarkers associated with cannabis use, adjusted for demographic characteristics and sampling weights. Cannabis use was considered as Never, Former, or Current (past 3-month) use. Thirteen plasma biomarkers were measured once on or after 2010 among a subset of PWH on antiretroviral therapy with HIV viral suppression within CNICS. Cannabis use was assessed within 1 year prior to biomarker collection. Biomarkers were log-transformed and scaled by standard deviation to standardize estimates.

resultsAmong 532 PWH, the average age at biomarker collection date was 47 years, 84% were male, 61% non-White, 30% reported current cannabis use, 35% former use, and 35% never using cannabis. In adjusted linear regression, current cannabis use was associated with higher soluble CD14 (sCD14) levels (β = 0.35; 95% confidence interval [CI]: 0.09, 0.61). Former cannabis use was associated with lower C-reactive protein (CRP) (β = -0.25; 95% CI: -0.47, -0.04), although current use was not (β = -0.25; 95% CI: -0.51, 0.01) compared to never use.

conclusionsCannabis use may be related to lower CRP and elevated markers of microbial translocation (e.g., sCD14), which could have implications in increasing the risk of vascular events and should be investigated in a longitudinal setting.

Indexed as

cannabisC-reactive proteinHIVinflammatory biomarkerssoluble CD14

Identifiers

PMID41883041
PMCPMC13094378

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.