Evidence map›Paper›PMID 41883006›Full record

ArticleJournal of Alzheimer's disease : JAD2026

Generalizability of blood-based biomarkers of Alzheimer's disease and related dementias in a multicultural cohort of older adults: The effect of adjustment for kidney function.

Ángel García de la Garza, Cuiling Wang, Carol A Derby, Qi Gao, Kenny Q Ye, Henrik Zetterberg, Christopher G Engeland, Richard B Lipton, Mindy J Katz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Brain, behavior, & immunity - health · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ángel García de la GarzaDivision of Biostatistics, Department of Epidemiology, Albert Einstein College of Medicine, The Bronx, NY, USA.ORCID 0000-0001-6062-5190
Cuiling WangDivision of Biostatistics, Department of Epidemiology, Albert Einstein College of Medicine, The Bronx, NY, USA.
Carol A DerbySaul R. Korey Department of Neurology, Albert Einstein College of Medicine, The Bronx, NY, USA.
Qi GaoDivision of Biostatistics, Department of Epidemiology, Albert Einstein College of Medicine, The Bronx, NY, USA.ORCID 0000-0002-1236-8641
Kenny Q YeDivision of Biostatistics, Department of Epidemiology, Albert Einstein College of Medicine, The Bronx, NY, USA.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Christopher G EngelandDepartment of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA.ORCID 0000-0002-1073-373X
Richard B LiptonSaul R. Korey Department of Neurology, Albert Einstein College of Medicine, The Bronx, NY, USA.ORCID 0000-0003-2652-2897
Mindy J KatzSaul R. Korey Department of Neurology, Albert Einstein College of Medicine, The Bronx, NY, USA.ORCID 0009-0004-7524-0292

Funding

Vascular Structure and Function in Cognitive AgingP01AG003949 · NIA · YESHIVA UNIVERSITY · PI Richard B. LIPTON · 1985 to 2026
$73.9M
Pen-and-Paper and Smartphone Self-Reported Cognitive Concerns to Predict Longitudinal Alzheimer's Biomarkers in a Diverse, Non-Demented Older Adult PopulationR03AG095655 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI GARCIA DE LA GARZA, ANGEL · 2025 to 2025
$336k
NIA NIH HHS P01 AG003949NIA NIH HHS R03 AG095655
6 · The paper itself

Abstract

BackgroundInterpreting blood-based biomarkers of Alzheimer's disease and related dementias (ADRD) in a multicultural cohort is complicated by inconsistent evidence on racial differences. Kidney function, which varies by race and influences biomarker levels, is often overlooked, potentially contributing to these inconsistencies.ObjectiveTo characterize racial differences in plasma levels of ADRD biomarkers after adjusting for comorbidities and assessed the impact of estimated glomerular filtration rate (eGFR) adjustment using either race-specific or race-neutral equations.MethodsData from the Einstein Aging Study, a multicultural cohort of older adults, included plasma biomarkers (Aβ

Indexed as

Alzheimer DiseaseAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersBlack or African AmericanCohort StudiesFemaleGlomerular Filtration RateHumansMalePeptide FragmentsWhiteAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersPeptide FragmentsAlzheimer's diseaseblood-based biomarkerscomorbiditieskidney functionmulticultural cohort

Identifiers

PMID41883006
PMCPMC13178941

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.