Evidence map›Paper›PMID 41882939›Full record

ReviewAngewandte Chemie (International ed. in English)2026

Navigating Nitration Chemistry: A Practical Guide to Reagents, Mechanisms, and Selectivity.

Harry Lecomte, Anthony J Fernandes, Dmitry Katayev

Abstract readReview
In one paragraph

Review in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Harry LecomteDepartment Für Chemie und Biochemie, Universität Bern, Bern, Switzerland.ORCID https://orcid.org/0009-0003-0438-5761
Anthony J FernandesDepartment Für Chemie und Biochemie, Universität Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0001-8372-7982
Dmitry KatayevDepartment Für Chemie und Biochemie, Universität Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0003-0131-1188

Funding

Swiss National Science Foundation PCEFP2_186964
6 · The paper itself

Abstract

We highlight recent advances in nitration chemistry with emphasis on the development of sustainable and selective methodologies. A comprehensive overview of nitrating reagents is provided, classified by origin (organic or inorganic) and activation mode (photochemical, electrochemical, thermal, and others). Each reagent is critically analyzed with respect to its performance across different nitration processes, that is, aromatic, ipso-, olefinic, alkyne, and heteroatom nitration. This analysis scrutinizes yield, substrate scope, functional group tolerance, versatility, resource and hazard, key features that comprise an efficiency score. A comparative analysis of activation strategies underscores the evolution of nitration from classical mixed-acid approaches to modern photocatalytic, electrochemical, and cross-coupling methodologies. The insights gathered here provide a practical framework for identifying the most suitable nitrating reagents and highlight future directions toward safer, greener, and more versatile nitration chemistry.

Indexed as

electrophilicmechanismsnitrationradicalreagents

Identifiers

PMID41882939
PMCPMC13159431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.