Evidence map›Paper›PMID 41882887›Full record

ReviewChemistryOpen2026

DNAzyme-Based Nanostructures for Dynamic Cell Regulation and Sensing.

Haoyu Fan, Xichen Du, Ruocan Qian

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ChemistryOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Haoyu FanInternational Elite Engineering School, East China University of Science and Technology, Shanghai, China.
Xichen DuKey Laboratory for Advanced Materials, Feringa Nobel Prize Scientist Joint Research Center, Joint International Laboratory for Precision Chemistry, Frontiers Science Center for Materiobiology & Dynamic Chemistry School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, P. R. China.
Ruocan QianKey Laboratory for Advanced Materials, Feringa Nobel Prize Scientist Joint Research Center, Joint International Laboratory for Precision Chemistry, Frontiers Science Center for Materiobiology & Dynamic Chemistry School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, P. R. China.ORCID 0000-0002-1039-9866

Funding

Fundamental Research Funds for Central Universities of the Central South University 222201717003Innovative Research Group Project of the National Natural Science Foundation of China 21977031Science and Technology Innovation Plan Of Shanghai Science and Technology Commission 22ZR1416800
6 · The paper itself

Abstract

This review systematically explores the cutting-edge advancements in DNAzyme-based nanostructures for dynamic cellular regulation and biosensing. As catalytic DNA molecules, DNAzymes exhibit high stability, programmability, and versatile functionality, making them powerful tools for diverse applications, including metal ion detection, controlled cell-cell interactions, and high-resolution bioimaging. By integrating with nanomaterials such as liposomes, gold nanoparticles, and metal-organic frameworks, DNAzyme systems have overcome inherent limitations such as nuclease susceptibility and poor cellular uptake, thereby significantly enhancing their performance and stability in complex biological environments. Key innovations discussed include logic-gated systems for programmable cell assembly, rRNA-activated sensors for subcellular imaging, and DNAzyme-driven nanodevices like walkers and tweezers for amplified sensing and intracellular manipulation. These developments pave the way for novel therapeutic strategies in targeted gene silencing and combination cancer therapy. Finally, we highlight future directions focusing on context-responsive nanocarriers, multimodal theranostic platforms, and scalable biocompatible designs to promote the clinical translation of DNAzyme technologies.

Indexed as

Biosensing TechniquesDNA, CatalyticNanostructuresAnimalsGoldHumansMetal NanoparticlesDNA, CatalyticGoldbioimagingbiosensingcell regulationDNAzymenanostructure

Identifiers

PMID41882887
PMCPMC13140643

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.