Evidence map›Paper›PMID 41882771›Full record

ArticleBiology of sex differences2026

Sex differences in the clinical outcomes of chronic hepatitis B infection among paediatric patients.

Wenxian Ouyang, Zhenzhen Yao, Yingping Gu, Xin Lai, Songxu Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of sex differences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenxian Ouyang *Liver Disease Center, Hunan Children's Hospital, Changsha, China.
Zhenzhen Yao *Department of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha, 410013, China.
Yingping GuDepartment of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha, 410013, China.
Xin LaiDepartment of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha, 410013, China.
Songxu PengDepartment of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha, 410013, China. gwxypsx@163.com.

Funding

National Natural Science Foundation of China 82103861Natural Science Foundation of Hunan Province, China 2024JJ5457
6 · The paper itself

Abstract

backgroundThe impacts of sex on treatment response in paediatric patients with chronic hepatitis B virus (HBV) infection remains incompletely understood. We aimed to analyse sex differences in antiviral treatment response in children with HBV infection.

methodsWe performed a retrospective cohort study on 236 treatment-naive children with chronic HBV infection at the Liver Disease Centre of Hunan Children's Hospital. The Cox proportional hazard regression was used to estimated treatment outcome differences between males and females.

resultsOf the 236 subjects, the median age at treatment initiation was 4 (2,7) years, and 155 (65.68%) were male. After the median follow-up (IQR) of 27 (18, 43) months, the crude cumulative incidence of HBsAg loss, HBeAg clearance and HBV DNA undetectability in patients were 48.73%, 61.02% and 89.36%, respectively. Kaplan-Meier curve showed that female patients were more likely to achieving HBsAg loss compared to male patients (58.02% vs. 43.87%, P

conclusionChildren with chronic HBV infection receiving antiviral treatment are frequently observed to achieve functional cure. Sex plays an important role in treatment response among paediatric patients, with female patients exhibiting a higher likelihood of achieving HBsAg loss, particularly after one- year of follow-up.

Indexed as

Antiviral AgentsHepatitis B, ChronicSex CharacteristicsChildChild, PreschoolFemaleHepatitis B e AntigensHepatitis B Surface AntigensHumansMaleRetrospective StudiesTreatment OutcomeAntiviral AgentsHepatitis B e AntigensHepatitis B Surface AntigensChildrenChronic hepatitis B virus infectionDifferenceSexTreatment response

Identifiers

PMID41882771
PMCPMC13141448

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.