ArticleTrials2026
Radiofrequency ablation for the treatment of chronic pain after knee arthroplasty: protocol for a randomized, double-blind study.
Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05920382 (Radiofrequency Ablation for the Treatment of Post-knee Arthroplasty Chronic Pain. A Randomized Double-blind Study. A Novel Approach.), which is not on this map. Not yet cited in PubMed.
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Radiofrequency Ablation for the Treatment of Post-knee Arthroplasty Chronic Pain. A Randomized Double-blind Study. A Novel Approach.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTo date, there is no standard treatment for chronic pain after knee arthroplasty. Radiofrequency ablation of the sensory nerves in the knee has become a useful therapeutic approach; however, variability in terms of treatment approaches and anatomical targets causes difficulties in standardizing a reproducible and viable technique. The aim of this study is to determine if radiofrequency ablation of the nerves of the vastus medialis (NVM), vastus intermedius (NVI), vastus lateralis (NVL), and infrapatellar branch of the saphenous nerve (IPBSN) improves pain and disability from baseline to 3 months versus placebo in patients with post-knee arthroplasty pain.
methodsThis double-blind, placebo-controlled, randomized trial will be conducted in two hospitals in Catalonia, Spain. Patients will undergo anaesthetic blocks of nerve branches to determine radiofrequency candidacy. After adequate response to the anaesthetic blocks (≤ 50% of baseline pain levels for > 24 h), patients will be subjected to radiofrequency ablations or control simulations. Treatment responses will be evaluated using clinically validated questionnaires (Western Ontario McMaster Universities Osteoarthritis Index [WOMAC], visual numerical scale for pain, DN4 questionnaire for neuropathic pain, Hospital Anxiety and Depression Scale [HADS], Pain Catastrophizing Scale [PCS]). Follow-up outcome scores will be collected up to 12 weeks after radiofrequency ablation. DISCUSSION: The planned sample size is 86 patients. As of February 19, 2025, a total of 19 patients have been enrolled, and 12 have completed all study procedures.
trial registrationNCT05920382.
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