Evidence map›Paper›PMID 41882744›Full record

ReviewHuman genomics2026

Translating multi-omics into healthcare: requisites for scalable and equitable implementation.

Birute Tumiene, David R Adams, Robert Allaway, Maria J Barrero, Chun-Hung Chan, Víctor Faundes, Vanessa S Fear, Polina Glezer, Claudia Fuchs, Tudor Groza and 11 more

Abstract readReview
In one paragraph

Review in Human genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Birute TumieneFaculty of Medicine, Institute of Biomedical Sciences, Vilnius University Hospital Santaros Klinikos, Vilnius University, Vilnius, Lithuania.
David R AdamsNational Human Genome Research Institute, National Institutes of Health, Bethesda, USA.
Robert AllawaySage Bionetworks, Seattle, USA.
Maria J BarreroInstitute of Rare Diseases Research (IIER), Spanish National Institute of Health Carlos III (ISCIII), Madrid, Spain.
Chun-Hung ChanSanford Research, Sioux Falls, USA.
Víctor FaundesLaboratorio de Genética y Enfermedades Metabólicas, Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago, Chile.
Vanessa S FearThe Kids Research Institute Australia, Nedlands, Australia.
Polina GlezerChan Zuckerberg Initiative, Redwood City, CA, USA.
Claudia FuchsEURORDIS, Rare Diseases Europe, Paris, France.
Tudor GrozaSingHealth Duke-NUS Institute of Precision Medicine, Singapore, Singapore.
Elisa J F HouwinkDepartment of Family Medicine, Mayo Clinic, Rochester, MN, USA.
Saumya Shekhar JamuarSingHealth Duke-NUS Institute of Precision Medicine, Singapore, Singapore.
Mary Catherine V LetinturierIRDiRC Scientific Secretariat, French National Institute of Health and Medical Research (Inserm), Ivry-sur-Seine, France.
Richa Madan LomashNational Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Maryland, USA.
Ratna Dua PuriSir Ganga Ram Hospital, New Delhi, India.
Juergen K V ReichardtAustralian Institute of Tropical Health and Medicine, James Cook University, Douglas, Australia.
Ruty Mehrian-ShaiThe Scojen Institute for Synthetic Biology, Reichman University, Herzliya, Israel.
Francois H van der WesthuizenBiomedical and Molecular Metabolism Research (BioMMet), North-West University, Potchefstroom, South Africa.
Gaurav K VarshneyGenes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, USA.
Shinya YamamotoBaylor College of Medicine, Houston, USA.
Gareth BaynamRare Care Centre, Perth Children's Hospital and Western Australian Register of Developmental Anomalies, King Edward Memorial Hospital, Subiaco, Australia. gareth.baynam@health.wa.gov.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multi-omics in combination with advanced computational methodologies synthesizes diverse omics data to provide deeper insights into molecular interactions and offers transformative potential for unravelling phenomenon behind disease complexities, improving diagnostics, disease prevention, and personalized treatments. This integrative strategy enables our understanding of gene-environment relationships, chronic disease progression, and the intricate molecular pathways involved in health. Effective multi-omics analyses require robust data sharing, accessibility, interoperability, and governance, which are critical for linking genomic elements to phenotypic traits. The Global Alliance for Genomics and Health advocates for responsible data-sharing practices, by promoting key principles such as transparency and equity. By emphasizing a collaborative approach to data utilization, our proposed framework seeks to advance improved disease prevention and treatment strategies. Multi-disciplinary collaboration, encompassing researchers, clinicians, policy makers, and patient representatives, is pivotal for driving innovation and addressing rare disease diagnostics. The success of multi-omics applications hinges on the establishment of comprehensive datasets, understanding the functional implications of multi-omic variation, adherence to findable, accessible, interoperable, reusable (FAIR) and Collective Benefit, Authority to Control, Responsibility, and Ethics (CARE) principles, and the strengthening of global genomic commons, benefiting scientific research, drug development, and broader health initiatives. Our review highlights essential components of multi-omics integration, underscoring its potential to transform the landscape of precision medicine and improved patient outcomes worldwide.

Indexed as

Delivery of Health CareGenomicsMultiomicsHumansInformation DisseminationPrecision MedicineTranslational Research, BiomedicalHealth dataHealth equityMulti modal dataOmicsRare diseases

Identifiers

PMID41882744
PMCPMC13085408

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.