ArticleReproductive biology and endocrinology : RB&E2026
Improved progressive motility recovery with a standardized gradient-based approach for semen preparation in IUI.
Article in Reproductive biology and endocrinology : RB&E, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate the laboratory performance of a standardized gradient-based sperm preparation system designed to improve progressive motility recovery during density gradient centrifugation for intrauterine insemination (IUI).
designRetrospective, multicenter laboratory cohort study. SUBJECTS: A total of 13,416 semen samples processed for IUI.
interventionsComparison between a conventional density gradient centrifugation method and a standardized gradient-based preparation system (RS system) incorporating controlled gradient layering and direct pellet retrieval.
main outcome measuresPost-/pre-preparation progressive motility ratio, post-preparation sperm concentration, and descriptive baseline characteristics.
resultsThe standardized system demonstrated significantly higher progressive motility recovery compared with the conventional density gradient method (mean post-/pre-preparation progressive motility ratio 1.60 vs. 1.48; p < 0.001). These findings suggest that procedural differences in sperm preparation may influence the enrichment of progressively motile spermatozoa under routine laboratory conditions.
conclusionsThis large laboratory-based analysis indicates that a standardized gradient-based sperm preparation approach is associated with improved progressive motility recovery compared with a conventional density gradient method. The findings highlight the potential importance of procedural standardization in sperm preparation for IUI. As clinical outcomes were not assessed, prospective studies are required to determine whether these laboratory differences translate into improved reproductive outcomes.
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