Evidence map›Paper›PMID 41882679›Full record

ArticleGenome biology2026

Alu-mediated RNA duplexes are associated with widespread exon skipping across primate transcriptomes.

Hyunbeen Lee, Xinang Cao, Guillermo E Parada, Jack Daiyang Li, Ira A Iosub, Ulrich Braunschweig, Kenny Rebelo, Jernej Ule, Yue Wan, Benjamin J Blencowe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hyunbeen Lee *Donnelly Centre, University of Toronto, Toronto, ON, Canada.
Xinang Cao *Genome Institute of Singapore, A*STAR, Singapore, Singapore.
Guillermo E Parada *Donnelly Centre, University of Toronto, Toronto, ON, Canada. guillermo_parada@kcl.ac.uk.
Jack Daiyang LiDonnelly Centre, University of Toronto, Toronto, ON, Canada.
Ira A IosubBrain RNA Networks Laboratory, Francis Crick Institute, London, UK.
Ulrich BraunschweigDonnelly Centre, University of Toronto, Toronto, ON, Canada.
Kenny RebeloDonnelly Centre, University of Toronto, Toronto, ON, Canada.
Jernej UleBrain RNA Networks Laboratory, Francis Crick Institute, London, UK.
Yue WanGenome Institute of Singapore, A*STAR, Singapore, Singapore. wany@a-star.edu.sg.
Benjamin J BlencoweDonnelly Centre, University of Toronto, Toronto, ON, Canada. b.blencowe@utoronto.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alternative splicing patterns have diverged rapidly during vertebrate evolution. By integrating genome-wide predictions of stable RNA duplexes, alternative splicing profiles, and proximity ligation-detection of RNA-RNA interactions, we observe that the majority of long-range intronic RNA duplexes are mediated by inverted Alu-repeat elements, and that these structures are associated with divergent exon skipping patterns in primates. We further observe evidence that the RNA binding proteins HNRNPC, ILF2 and ILF3 directly control Alu duplex-associated alternative splicing levels. Collectively, our results provide evidence that Alu-derived RNA duplexes modulated by RNA binding proteins have contributed to the remarkable divergence in alternative splicing patterns during mammalian evolution.

Indexed as

Alternative SplicingAlu ElementsExonsPrimatesRNATranscriptomeAnimalsEvolution, MolecularHeterogeneous-Nuclear Ribonucleoprotein Group CHumansIntronsNuclear Factor 90 ProteinsRNA-Binding ProteinsHeterogeneous-Nuclear Ribonucleoprotein Group CNuclear Factor 90 ProteinsRNARNA-Binding Proteins

Identifiers

PMID41882679
PMCPMC13019944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.