ArticleJournal of occupational medicine and toxicology (London, England)2026
Assessment of spirometric decline from silica dust: threshold values and calculation methods for cumulative exposure.
Article in Journal of occupational medicine and toxicology (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis study investigates the association between crystalline silica dust exposure and lung function decline. Understanding whether exposure-response relationships include threshold values is critical for contributing to workplace health protection. We compared four mechanistically different models to determine which best characterizes this association.
methodsData from 1,418 workers from the Wismut German Uranium Mining Cohort Study from 1970 to 1991 with 7,116 spirometry measurements were analysed. Cumulative exposure was calculated using a job exposure matrix. Four models based on different pathophysiological mechanisms were compared: (1) constant annual threshold without overload, (2) constant annual threshold with overload, (3) delayed onset (cumulative threshold only), and (4) dynamic threshold decreasing over time.
resultsModels 1, 3 and 4 showed a critical annual exposure value of approximately 0.09-0.10 mg/m
conclusionThe results confirm that high silica dust exposure leads to an accelerated decline in lung function. Model 1 appears to be the most appropriate, despite limitations such as limited age range and sole focus on spirometry. The results demonstrate an association between cumulative silica dust exposure above approximately 0.09 mg/m
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