Observational studyBMC infectious diseases2026
Health-related quality of life and associated factors among hospitalized dengue patients in Bangladesh: a cross-sectional study.
Observational study in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDengue is an increasing public health concern in Bangladesh, but its impact on health-related quality of life (HRQoL) remains poorly explored. In 2024, Bangladesh experienced a substantial rise in dengue cases. This study aimed to assess the HRQoL of hospitalized dengue patients in Bangladesh and identify its associated factors.
methodsThe cross-sectional observational study was conducted among hospitalized dengue patients in Bangladesh. HRQoL was measured using the EQ-5D-3L. Multivariable regression models examined the associations between demographic, socio-economic, and clinical factors and HRQoL outcomes (EQ-5D-3L index and EQ-VAS scores).
resultsA total of 490 hospitalized dengue patients were included, with a median age of 27 years. The majority of the patients were aged below 40 years (79%), male (80%), and residing in urban areas (73%). Group B (70%) had the highest dengue severity among participants. Most of the participants experienced problems regarding mobility (86%), self-care (80%), usual activities (85%), pain (89%), and anxiety/depression (82%). The mean EQ-5D-3L index score was 0.46 ± 0.38, and the median EQ-VAS score was 50 (IQR: 30-60). Severe dengue (Group C) was associated with the poorest HRQoL (index: 0.12 ± 0.35; VAS: 28.82 ± 16.78), compared to Group A (index: 0.62 ± 0.35; VAS: 41.02 ± 18.98; p < 0.001). Patients aged ≥60 years reported lower HRQoL (index: 0.32 ± 0.39; VAS: 35.63 ± 16.72; p < 0.001) than younger age groups. Comorbid patients had significantly reduced HRQoL (index: 0.23 ± 0.38 vs. 0.50 ± 0.36; VAS: 37.80 ± 18.22 vs. 45.72 ± 18.69; p < 0.001). Males reported higher EQ-VAS scores than females (45.65 ± 19.50 vs. 39.90 ± 14.98; p = 0.007), while urban residents had lower self-rated health than rural residents (43.44 ± 19.24 vs. 47.46 ± 17.32; p = 0.037). Multivariable regression confirmed that dengue severity, age, and comorbidities were independent predictors of both EQ-5D-3L index and EQ-VAS scores.
conclusionsThis study highlights the significant impact of dengue on HRQoL and identifies key factors associated with reduced well-being among hospitalized dengue patients in Bangladesh. These findings underscore the need for targeted interventions, particularly in vulnerable populations in resource-constrained settings, and call for further research to guide patient-centered care for this disease.
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