Observational studyBMC anesthesiology2026
Oxygenator-related gaseous microemboli and postoperative delirium after on-pump coronary artery bypass grafting: a prospective cohort study.
Observational study in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe increasing preference for off-pump coronary artery bypass grafting (CABG) reflects efforts to reduce complications associated with cardiopulmonary bypass (CPB). A lower incidence of postoperative delirium (POD) after off-pump procedures suggests that embolic load during CPB may contribute to postoperative neurocognitive impairment. Oxygenator design may influence the generation and transmission of gaseous microemboli (GME) during CPB. This study aimed to determine whether differences in oxygenator design affect the GME-handling characteristics of the CPB circuit and to evaluate the clinical implications of microembolic burden in patients undergoing on-pump CABG.
methodsIn this prospective, non-interventional observational study, 102 adult patients undergoing first-time isolated on-pump CABG were included. Patients were supported with one of three contemporary membrane oxygenators (Capiox FX25, Inspire 8, or Inspire 8 F). Gaseous microemboli number and cumulative volume were continuously measured proximal and distal to the oxygenator using an ultrasonic microbubble counter. Postoperative delirium was assessed every 12 h during the first postoperative week using the Confusion Assessment Method for the ICU and the Richmond Agitation–Sedation Scale by assessors blinded to oxygenator type.
resultsBaseline characteristics, operative variables, and venous GME burden were comparable among groups. Use of the Capiox FX25 oxygenator was associated with significantly lower arterial GME volume and the greatest reduction in microembolic volume compared with both Inspire oxygenators. Inspire 8 demonstrated the lowest reduction in GME number. Postoperative delirium occurred in 29.4% of patients and was least frequent in the Capiox FX25 group.
conclusionsOxygenator design significantly influences intraoperative gaseous microembolic burden and is associated with differences in postoperative delirium after on-pump CABG. Oxygenator selection may represent a modifiable intraoperative factor affecting postoperative neurocognitive outcomes.
trial registrationAs this was a non-interventional, observational study with no deviation from standard clinical practice, registration in a public clinical trial registry was not required.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.