Evidence map›Paper›PMID 41882505›Full record

ReviewScandinavian journal of immunology2026

COVID-19 and Pregnancy: Key Findings.

Gabrielle Gimenes Lima, Ana Flávia Segati, Giovanna Santos Oliveira, Nicoly Simões de Melo, Túlio Nakazato da Cunha, Elizabeth De Gaspari

Abstract readReview
In one paragraph

Review in Scandinavian journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gabrielle Gimenes LimaImmunology Center, Adolfo Lutz Institute, São Paulo, Brazil.
Ana Flávia SegatiImmunology Center, Adolfo Lutz Institute, São Paulo, Brazil.
Giovanna Santos OliveiraImmunology Center, Adolfo Lutz Institute, São Paulo, Brazil.
Nicoly Simões de MeloImmunology Center, Adolfo Lutz Institute, São Paulo, Brazil.
Túlio Nakazato da CunhaImmunology Center, Adolfo Lutz Institute, São Paulo, Brazil.
Elizabeth De GaspariImmunology Center, Adolfo Lutz Institute, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-8332-2248

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 131308/2021-1Conselho Nacional de Desenvolvimento Científico e Tecnológico 132059/2025-8Conselho Nacional de Desenvolvimento Científico e Tecnológico 305301/2022-5Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance code 001Fundação de Amparo à Pesquisa do Estado de São Paulo 18/04202-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/11936-3
6 · The paper itself

Abstract

Pregnant individuals were prioritised for COVID-19 research due to concerns about increased susceptibility and limited clinical trial data. This narrative review synthesises evidence on maternal infection, immunological adaptations, placental susceptibility, and antibody transfer following maternal SARS-CoV-2 vaccination. Symptomatic COVID-19 during pregnancy increases risks of severe outcomes, whereas vertical transmission remains rare. Placental pathology is characterised mainly by maternal vascular malperfusion and inflammation, with limited evidence of direct viral infection. Maternal vaccination-particularly with mRNA vaccines-induces robust IgG responses with efficient transplacental and lactational transfer, conferring passive neonatal protection. Key uncertainties include optimal vaccine timing, durability of neonatal immunity, and variant-specific responses. Strengthening standardised research and ensuring inclusion of pregnant individuals is essential for global maternal health policy.

Indexed as

COVID-19COVID-19 VaccinesPregnancy Complications, InfectiousSARS-CoV-2Antibodies, ViralFemaleHumansImmunity, Maternally-AcquiredInfectious Disease Transmission, VerticalPlacentaPregnancyVaccinationAntibodies, ViralCOVID-19 Vaccinesimmune responseimmunisationpregnancySARS‐CoV‐2vaccine

Identifiers

PMID41882505
PMCPMC13018292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.