Evidence map›Paper›PMID 41882460›Full record

ArticleAAPS PharmSciTech2026

From Liquid to Solid: Formulation and Characterization of Testosterone-Loaded S-SMEDDS Pellets Using a 2

Ohary de Sousa Borges, Julia Ornelas Kramer, Henrique Pascoa, Yanka Machado de Paula Santos, Leticia Silva Oliveira Freitas, Eliana M Lima, Luís Antônio Dantas Silva, Danielle Guimarães A Diniz

Abstract read
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In one paragraph

Article in AAPS PharmSciTech, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ohary de Sousa BorgesCenter for R&D and Innovation in Pharmaceutical Technology and Nanomedicine, Federal University of Goiás, Goiânia, GO, Brazil.ORCID http://orcid.org/0000-0003-2787-0666
Julia Ornelas KramerCenter for R&D and Innovation in Pharmaceutical Technology and Nanomedicine, Federal University of Goiás, Goiânia, GO, Brazil.ORCID http://orcid.org/0009-0008-6335-4566
Henrique PascoaCenter for R&D and Innovation in Pharmaceutical Technology and Nanomedicine, Federal University of Goiás, Goiânia, GO, Brazil.ORCID http://orcid.org/0000-0003-2542-6879
Yanka Machado de Paula SantosCenter for R&D and Innovation in Pharmaceutical Technology and Nanomedicine, Federal University of Goiás, Goiânia, GO, Brazil.ORCID http://orcid.org/0009-0002-8946-3142
Leticia Silva Oliveira FreitasCenter for R&D and Innovation in Pharmaceutical Technology and Nanomedicine, Federal University of Goiás, Goiânia, GO, Brazil.ORCID http://orcid.org/0009-0009-6531-0695
Eliana M LimaCenter for R&D and Innovation in Pharmaceutical Technology and Nanomedicine, Federal University of Goiás, Goiânia, GO, Brazil.ORCID http://orcid.org/0000-0003-1231-5803
Luís Antônio Dantas SilvaCenter for R&D and Innovation in Pharmaceutical Technology and Nanomedicine, Federal University of Goiás, Goiânia, GO, Brazil.ORCID http://orcid.org/0000-0001-5328-237X
Danielle Guimarães A DinizCenter for R&D and Innovation in Pharmaceutical Technology and Nanomedicine, Federal University of Goiás, Goiânia, GO, Brazil. danielle_diniz@ufg.br.ORCID http://orcid.org/0000-0003-1867-3521

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The solidification of self-microemulsifying drug delivery systems (SMEDDS) represents a significant advance in the transition from self-microemulsifying technology to industrial-scale production. A solid self-microemulsifying drug delivery system of testosterone (TST/S-SMEDDS) was developed using the extrusion-spheronization technique, with the aim of converting the liquid SMEDDS into a solid dosage form. Testosterone-loaded S-SMEDDS pellets were formulated based on a 2

Indexed as

TestosteroneBulk DrugsCalorimetry, Differential ScanningChemistry, PharmaceuticalDrug CompoundingDrug Delivery SystemsEmulsionsExcipientsParticle SizeSolubilitySpectroscopy, Fourier Transform InfraredThermogravimetryBulk DrugsEmulsionsExcipientsTestosteronedrug delivery systemdrug-excipient interactionfactorial designlipid-based formulationsolid self-emulsifing system

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.