Evidence map›Paper›PMID 41882441›Full record

ArticleBiogerontology2026

Holotomography-based, label-free quantification of cellular dry mass as a biophysical indicator of microglial Aβ phagocytosis during senescence.

Sunjeet Saha, Amarnath Singam, Melanie White, Colbey Kimbel, Nikita Gopakumar, Jeong Hee Kim, Jingchun Chen, Ashkan Salamat, Seungman Park

Abstract read
PubMed Publisher
In one paragraph

Article in Biogerontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Sunjeet Saha *Department of Mechanical Engineering, University of Nevada, Las Vegas, NV, 89154, USA.
Amarnath Singam *Department of Mechanical Engineering, University of Nevada, Las Vegas, NV, 89154, USA.
Melanie WhiteNevada Extreme Conditions Laboratory, University of Nevada, Las Vegas, NV, 89154, USA.
Colbey KimbelDepartment of Mechanical Engineering, University of Nevada, Las Vegas, NV, 89154, USA.
Nikita GopakumarDepartment of Mechanical Engineering, University of Nevada, Las Vegas, NV, 89154, USA.
Jeong Hee KimDepartment of Mechanical Engineering, Iowa State University, Ames, IA, 50011, USA.
Jingchun ChenNevada Institute for Personalized Medicine, University of Nevada, Las Vegas, NV, 89154, USA.
Ashkan SalamatNevada Extreme Conditions Laboratory, University of Nevada, Las Vegas, NV, 89154, USA.
Seungman ParkDepartment of Mechanical Engineering, University of Nevada, Las Vegas, NV, 89154, USA. seungman.park@unlv.edu.

Funding

Characterization of relation between tissue viscoelasticity and tumor progression in aging tissuesK25AG070286 · NIA · UNIVERSITY OF NEVADA LAS VEGAS · PI PARK, SEUNGMAN · 2021 to 2025
$734k
NIA NIH HHS K25 AG070286NIA NIH HHS K25AG070286
6 · The paper itself

Abstract

Senescent microglia undergo significant molecular and biochemical changes associated with impaired phagocytosis of amyloid-β (Aβ), a process implicated in neurodegenerative disease progression. However, quantitative biophysical metrics capable of capturing this functional impairment-and thus elucidating the role of microglial dysfunction in disease progression-remain limited. In this study, we identify cellular dry mass, measured by label-free holotomography, in combination with cell and nuclear morphological features, as sensitive biophysical indicators of microglial senescence and phagocytic capacity. Microglial senescence was induced using optimized hydrogen peroxide (H

Indexed as

Amyloid beta-PeptidesCellular SenescenceMicrogliaPhagocytosisAnimalsCells, CulturedHydrogen PeroxideMiceAmyloid beta-PeptidesHydrogen PeroxideAmyloid-β (Aβ)Dry massHolotomographyMicroglial cellPhagocytosisSenescence

Identifiers

PMID41882441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.