CRP patterns and clinical associations in febrile patients undergoing autologous bone marrow transplant: experience from the sole transplant center in the West Bank, Palestine.

Ibrahim Ghoul, Maher Battat, Ahmad Khursani, Riad Amer, Mohamad Wild-Ali, Sawsan Muslm, Ramzi Shawahna, Mohammad Hayek

Abstract read

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Article in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Ibrahim GhoulOncology and Hematology department, An-Najah National University Hospital, An-Najah National University, Nablus, Palestine. i.ghoul@najah.edu.

Maher BattatLeukemia and Bone Marrow Transplantation Department, An-Najah National University Hospital, An-Najah National University, Nablus, Palestine.

Ahmad KhursaniOncology and Hematology department, An-Najah National University Hospital, An-Najah National University, Nablus, Palestine.

Riad AmerOncology and Hematology department, An-Najah National University Hospital, An-Najah National University, Nablus, Palestine. riadamer@najah.edu.

Mohamad Wild-AliOncology and Hematology department, An-Najah National University Hospital, An-Najah National University, Nablus, Palestine.

Sawsan MuslmOncology and Hematology department, An-Najah National University Hospital, An-Najah National University, Nablus, Palestine.

Ramzi ShawahnaDepartment of Physiology, Pharmacology and Toxicology, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.

Mohammad HayekFaculty of Medicine and Health Sciences, Nursing and Midwifery Department, An- Najah National University, Nablus, Palestine. m.hayek@najah.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autologous bone marrow transplantation (auto-BMT) is frequently complicated by febrile episodes and systemic inflammation, particularly during the neutropenic phase, making inflammatory markers such as C-reactive protein (CRP) valuable for monitoring recovery and guiding clinical decisions. In this descriptive, retrospective study of 244 febrile auto-BMT patients in the West Bank, data on demographics, CRP levels (days 1–14), fever onset and duration, and white blood cell (WBC) engraftment were analyzed using non-parametric tests and Spearman correlation. Fever typically began around day 6.7, lasted 6.5 days, and was accompanied by a CRP peak on day 8 (mean 104.8 mg/L) before gradually declining, while WBC engraftment occurred on day 12.96 (SD ± 5.29). CRP levels significantly differed by cancer type and conditioning regimen (p < .001), but not by gender, age, or comorbidities, and were weakly correlated with fever duration and negatively with fever onset. WBC engraftment day showed moderate correlations with fever duration and end. These findings suggest that CRP and fever patterns follow a predictable inflammatory course peaking around day 8, with engraftment timing significantly affecting fever duration, underscoring CRP’s potential as a supportive biomarker for post-transplant monitoring.

Indexed as

Bone Marrow TransplantationC-Reactive ProteinFeverAdolescentAdultAgedBiomarkersChildFemaleHumansMaleMiddle AgedMiddle EastRetrospective StudiesTransplantation, AutologousTransplantation ConditioningBiomarkersC-Reactive ProteinAutologous Bone Marrow Transplantation (Auto-BMT)Conditioning regimensC-Reactive Protein (CRP)Febrile neutropeniaFever patternsHematopoietic stem cell transplantationInflammatory biomarkersOncology outcomes and post-transplant monitoringWhite blood cell engraftment

Identifiers

PMID41882419

DOI10.1007/s00277-026-06967-5

PMCPMC13017986

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